UM  > 中華醫藥研究院
pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities
Zhang, Jinming1,2; Li, Jingjing1; Shi, Zhi3; Yang, Yang3; Xie, Xi4; Lee, Simon MingYuen1; Wang, Yitao1; Leong, Kam W.5; Chen, Meiwan1
2017-08
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume58Pages:349-364
Abstract

Co-delivery of multiple drugs with complementary anticancer mechanisms by nano-carriers offers an effective strategy to treat cancer. The combination of drugs with pro-apoptotic and anti-angiogenic activities is potentially effective in treating human hepatocellular carcinoma (HCC). Herein, we developed a co-delivery system for doxorubicin (Dox), a pro-apoptotic drug, and curcumin (Cur), a potent drug for antiangiogenesis, in pH-sensitive nanoparticles (NPs) constituted with amphiphilic poly(p-amino ester) copolymer. Dox & Cur co-loaded NPs ((D + C)/NPs) were prepared with optimized drug ratio, showing low polydispersity, high encapsulation efficiency, and enhanced release in the acidic environment of cancer cells. Furthermore, enhanced cellular internalization of cargoes delivered from (D + C)/NPs were observed in human liver cancer SMMC 7721 cells and human umbilical vein endothelial cells (HUVECs) compared to the use of free drugs. The (D + C)/NPs induced a high rate of apoptosis in SMMC 7721 cells through decreased mitochondrial membrane potential. Additionally, (D + C)/NPs exhibited stronger anti-angiogenic effects including inhibition of HUVEC proliferation, migration, invasion, and tube formation mediated VEGF pathway modulation in vitro and in vivo. Taken together, encapsulation of the pro-apoptotic drug Dox and antiangiogenic agent Cur in pH-sensitive NPs provides a promising strategy to effectively inhibit HCC progression in a synergistic manner.

KeywordAnticancer Ph-sensitive Nanoparticle Apoptosis Anti-angiogenesis Co-delivery
DOIhttp://doi.org/10.1016/j.actbio.2017.04.029
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000408077600032
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee, Simon MingYuen; Chen, Meiwan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
2.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3.Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China
4.Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA
5.Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, Jinming,Li, Jingjing,Shi, Zhi,et al. pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities[J]. ACTA BIOMATERIALIA,2017,58:349-364.
APA Zhang, Jinming.,Li, Jingjing.,Shi, Zhi.,Yang, Yang.,Xie, Xi.,...&Chen, Meiwan.(2017).pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities.ACTA BIOMATERIALIA,58,349-364.
MLA Zhang, Jinming,et al."pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities".ACTA BIOMATERIALIA 58(2017):349-364.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Jinming]'s Articles
[Li, Jingjing]'s Articles
[Shi, Zhi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Jinming]'s Articles
[Li, Jingjing]'s Articles
[Shi, Zhi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Jinming]'s Articles
[Li, Jingjing]'s Articles
[Shi, Zhi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.