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A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation
Ko, Chung-Nga1; Yang, Chao2; Lin, Sheng1; Li, Shengnan2; Dong, Zhenzhen1; Liu, Jinbiao1,3; Lee, Simon Ming-Yuen2; Leung, Chung-Hang2; Ma, Dik-Lung1
2017-08-15
Source PublicationBIOSENSORS & BIOELECTRONICS
ISSN0956-5663
Volume94Pages:575-583
Abstract

In this work, we report a novel iridium(III)-based luminescent switch on-off-on probe, for the in vitro and in vivo detection of sulfide ion. The mechanism of this platform is based on the effective charge transfer quenching of the iridium(III) complex 1 by Fe3+, followed by the restoration of luminescence upon the addition of Na2S. The probe, hereinafter referred to as 1 Fe3+, exhibited a linear range of detection for Na2S from 0.01 to 1.5 mM, with a detection limit of 2.9 1.1M at signal-to-noise ratio (S/N) of 3. We also demonstrate the utility of 1 Fe3+ for cell-based imaging as well as for the detection of enzymatic sulfide generation in living zebrafish.

KeywordIridum(Iii) Complex Endogenous Sulfide Production Sulfide Detection In livIng Organism
DOI10.1016/j.bios.2017.03.050
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS SubjectBiophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS IDWOS:000401201300076
PublisherELSEVIER ADVANCED TECHNOLOGY
The Source to ArticleWOS
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Co-First AuthorKo, Chung-Nga; Yang, Chao; Lin, Sheng
Corresponding AuthorMa, Dik-Lung
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
3.School of Metallurgical and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou, China
Recommended Citation
GB/T 7714
Ko, Chung-Nga,Yang, Chao,Lin, Sheng,et al. A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation[J]. BIOSENSORS & BIOELECTRONICS,2017,94:575-583.
APA Ko, Chung-Nga.,Yang, Chao.,Lin, Sheng.,Li, Shengnan.,Dong, Zhenzhen.,...&Ma, Dik-Lung.(2017).A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation.BIOSENSORS & BIOELECTRONICS,94,575-583.
MLA Ko, Chung-Nga,et al."A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation".BIOSENSORS & BIOELECTRONICS 94(2017):575-583.
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