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Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform
Liu, Jinshui1,2; Dong, Zhen-Zhen2; Yang, Chao3; Li, Guodong3; Wu, Chun2; Lee, Fu-Wa4; Leung, Chung-Hang3; Ma, Dik-Lung2
2017-08-21
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7
Abstract

A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, H2O2 can oxidize AgNPs to soluble Ag+ cations, which restores the luminescence of Ir-1. The sensing platform displayed a sensitive response to H2O2 in the range of 0-17 mu M, with a detection limit of 0.3 mu M. Importantly, the probe was successfully applied to monitor intracellular H2O2 in living cells, and it also showed high selectivity for H2O2 over other interfering substances.

DOI10.1038/s41598-017-09478-6
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000408107000114
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
4.Hong Kong Baptist Univ, Sch Continuing Educ, Coll Int Educ, Shek Mun, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jinshui,Dong, Zhen-Zhen,Yang, Chao,et al. Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Jinshui.,Dong, Zhen-Zhen.,Yang, Chao.,Li, Guodong.,Wu, Chun.,...&Ma, Dik-Lung.(2017).Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform.SCIENTIFIC REPORTS,7.
MLA Liu, Jinshui,et al."Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform".SCIENTIFIC REPORTS 7(2017).
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