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A Thermal Digital Microfluidic Device and Its Application to Disease Diagnostics
Jie Gao1; Liang Wan1; Yanwei Jia1; Tianlan Chen1; Cheng Dong1; Haoran Li1; Shun Liu1; Pui-In Mak1,2; Rui P. Martins1,2,3
2016
Conference NameLab on a Chip International Symposium: Droplet-based Microfluidics
Source PublicationLab on a Chip International Symposium: Droplet-based Microfluidics
Conference DateNov. 2016
Conference PlaceHang Zhou, China,
Other Abstract

Prompt point-of-care (POC) diagnostic tests based on amplification of pathogen DNAs are critical to effective treatment and control of infectious diseases. LoopMediated Isothermal Amplification (LAMP) is a potential powerful method for POC disease diagnostics as it is easy handling and cost effective with a short result turnaround time [1]. Especially, the DNA amplification can be observed with naked eyes by adding a DNA binding dye, Sybr Green I, into the final product solution. However, opening of the cap of the amplification tube may cause DNA contamination in the ambient environment inducing false-positive diagnosis later. To solve this problem, an enclosed system with internal sample manipulation is highly demanded. Digital microfluidics is a recently merged technique to manipulate (dispense, transport, mix and separate) microliter to nano-liter droplets containing biological/chemical samples on a two-dimensional electrodes array, which can reduce sample volume, provided fast heat transfer, has high reaction rate and possesses integration capacity.

URLView the original
Language英语
Fulltext Access
Document TypeConference paper
CollectionDEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
INSTITUTE OF MICROELECTRONICS
Affiliation1.State Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China
2.Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China
3.On leave from Instituto Superior Técnico, Universidade de Lisboa, Portugal
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Jie Gao,Liang Wan,Yanwei Jia,et al. A Thermal Digital Microfluidic Device and Its Application to Disease Diagnostics[C],2016.
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