UM  > 中華醫藥研究院
Schisandrin B regulates lipid metabolism in subcutaneous adipocytes
Kwan, Hiu Yee1; Wu, Jiahui1; Su, Tao1; Chao, Xiao-Juan1; Yu, Hua1,3; Liu, Bin2; Fu, Xiuqiong1; Tse, Anfernee Kai Wing1; Chan, Chi Leung1; Fong, Wang Fun1; Yu, Zhi-ling1

Subcutaneous adipocytes in obese subjects have a lower sensitivity to catecholamine-induced lipolysis and a higher sensitivity to insulin anti-lipolytic effects compared to adipocytes in other adipose depots. Therefore, increasing lipolysis in subcutaneous adipocytes coupled with enhanced fatty acid oxidation may be an anti-obesity strategy. Schisandrin B (Sch B) is one of the most abundant active dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis which is a commonly prescribed Chinese medicinal herb. We found that Sch B reduced glycerolipid contents in 3T3-L1 adipocytes and subcutaneous adipocytes dissected from DIO mice. Sch B also activated hormone sensitive lipase (HSL) and increased lipolysis in these adipocyte in a protein kinase A-dependent manner. Interestingly, Sch B increased fatty acid oxidation gene expressions in these adipocytes, implying an increase in fatty acid oxidation after treatment. In in vivo model, we found that Sch B increased HSL phosphorylation, reduced glycerolipid levels and increased fatty acid oxidation gene expressions in the subcutaneous adipocytes in the DIO mice. More importantly, Sch B significantly reduced the subcutaneous adipocyte sizes, subcutaneous adipose tissue mass and body weight of the mice. Our study provides scientific evidence to suggest a potential therapeutic function of Sch B or Schisandra chinensis seed containing Sch B in reducing obesity.

URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000408781200125
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKwan, Hiu Yee
Affiliation1.1School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
2.Guangzhou Institute of Cardiovascular Disease, Guangzhou Key Laboratory of Cardiovascular Disease, and the Second Afliated Hospital, Guangzhou Medical University, Guangzhou, China.
3.Present address: Institute of Chinese Medicine Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China.
Recommended Citation
GB/T 7714
Kwan, Hiu Yee,Wu, Jiahui,Su, Tao,et al. Schisandrin B regulates lipid metabolism in subcutaneous adipocytes[J]. SCIENTIFIC REPORTS,2017,7.
APA Kwan, Hiu Yee.,Wu, Jiahui.,Su, Tao.,Chao, Xiao-Juan.,Yu, Hua.,...&Yu, Zhi-ling.(2017).Schisandrin B regulates lipid metabolism in subcutaneous adipocytes.SCIENTIFIC REPORTS,7.
MLA Kwan, Hiu Yee,et al."Schisandrin B regulates lipid metabolism in subcutaneous adipocytes".SCIENTIFIC REPORTS 7(2017).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.