UM
Schisandrin B regulates lipid metabolism in subcutaneous adipocytes
Kwan, Hiu Yee; Wu, Jiahui; Su, Tao; Chao, Xiao-Juan; Yu, Hua; Liu, Bin; Fu, Xiuqiong; Tse, Anfernee Kai Wing; Chan, Chi Leung; Fong, Wang Fun; Yu, Zhi-ling
2017-08-31
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7
AbstractSubcutaneous adipocytes in obese subjects have a lower sensitivity to catecholamine-induced lipolysis and a higher sensitivity to insulin anti-lipolytic effects compared to adipocytes in other adipose depots. Therefore, increasing lipolysis in subcutaneous adipocytes coupled with enhanced fatty acid oxidation may be an anti-obesity strategy. Schisandrin B (Sch B) is one of the most abundant active dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis which is a commonly prescribed Chinese medicinal herb. We found that Sch B reduced glycerolipid contents in 3T3-L1 adipocytes and subcutaneous adipocytes dissected from DIO mice. Sch B also activated hormone sensitive lipase (HSL) and increased lipolysis in these adipocyte in a protein kinase A-dependent manner. Interestingly, Sch B increased fatty acid oxidation gene expressions in these adipocytes, implying an increase in fatty acid oxidation after treatment. In in vivo model, we found that Sch B increased HSL phosphorylation, reduced glycerolipid levels and increased fatty acid oxidation gene expressions in the subcutaneous adipocytes in the DIO mice. More importantly, Sch B significantly reduced the subcutaneous adipocyte sizes, subcutaneous adipose tissue mass and body weight of the mice. Our study provides scientific evidence to suggest a potential therapeutic function of Sch B or Schisandra chinensis seed containing Sch B in reducing obesity.
DOI10.1038/s41598-017-10385-z
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000408781200125
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Kwan, Hiu Yee,Wu, Jiahui,Su, Tao,et al. Schisandrin B regulates lipid metabolism in subcutaneous adipocytes[J]. SCIENTIFIC REPORTS,2017,7.
APA Kwan, Hiu Yee.,Wu, Jiahui.,Su, Tao.,Chao, Xiao-Juan.,Yu, Hua.,...&Yu, Zhi-ling.(2017).Schisandrin B regulates lipid metabolism in subcutaneous adipocytes.SCIENTIFIC REPORTS,7.
MLA Kwan, Hiu Yee,et al."Schisandrin B regulates lipid metabolism in subcutaneous adipocytes".SCIENTIFIC REPORTS 7(2017).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kwan, Hiu Yee]'s Articles
[Wu, Jiahui]'s Articles
[Su, Tao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.