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Poly(epsilon-caprolactone)-containing graft copolymers for ratiometric extracellular oxygen sensing
Zou, Xianshao; Pan, Tingting; Jiang, Jiapei; Li, Gang; Song, Cheng; Sun, Ruofan; Yang, Ziyun; Sun, Dazhi; Hou, Chunhui; Chen, Meiwan; Tian, Yanqing
2017-09
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume248Pages:108-118
AbstractA graft copolymer composed of poly(epsilon-caprolactone) as a hydrophobic chain and poly(N-(2hydroxypropyl)methacrylamide) as a hydrophilic segment with an internal reference probe for oxygen sensing was prepared. Highly efficient platinum(II)meso-tetra(pentafluorophenyl)porphine (PtTFPP) was used as a typical oxygen probe. Although PtTFPP was highly efficient, it is hydrophobic, limiting its direct application for oxygen sensing in biological conditions. By using the amphiphilic graft copolymer, PTTFPP was successfully incorporated into the micelles formed by this polymer to not only enable the application of PtTFPP for biosensing in medium but also retain its high efficiency. The quantum efficiency of PtTFPP in the micelle solution under nitrogen can reach as high as 0.20. The PtTFPP-containing micelles were tested for high throughput cell respiration and bacteria detection. The influence of an antibiotic, antimycin as a representative example, on cell respiration was also studied. For achieving high accurate sensing, an internal built-in reference probe with aggregation induced emission properties were also polymerized in the graft copolymer. This study demonstrated that the graft polymer approach is a good way to enable highly efficient and hydrophobic oxygen probes for biosensing. (C) 2017 Elsevier B.V. All rights reserved.
KeywordOxygen sensor Ratiometric sensor Graft copolymer Oxygen consumption Micelles
DOI10.1016/j.snb.2017.03.126
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000403772200015
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zou, Xianshao,Pan, Tingting,Jiang, Jiapei,et al. Poly(epsilon-caprolactone)-containing graft copolymers for ratiometric extracellular oxygen sensing[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,248:108-118.
APA Zou, Xianshao.,Pan, Tingting.,Jiang, Jiapei.,Li, Gang.,Song, Cheng.,...&Tian, Yanqing.(2017).Poly(epsilon-caprolactone)-containing graft copolymers for ratiometric extracellular oxygen sensing.SENSORS AND ACTUATORS B-CHEMICAL,248,108-118.
MLA Zou, Xianshao,et al."Poly(epsilon-caprolactone)-containing graft copolymers for ratiometric extracellular oxygen sensing".SENSORS AND ACTUATORS B-CHEMICAL 248(2017):108-118.
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