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Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material
Niu, Yiming1; Li, Qiu1; Xie, Ruiyu3; Liu, Shang2; Wang, Ruibing1; Xing, Panfei1; Shi, Yuchen1; Wang, Yitao1; Dong, Lei2; Wang, Chunming1
2017-09
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume139Pages:39-55
Abstract

The biomaterials-host interaction is a dynamic process in which macrophages play a vital role of regulation. Depending on the biochemical signals they sense, these highly plastic cells can mediate the immune response against the implanted scaffolds and/or exert regenerative potency to varying extent. Designing appropriate 'exterior signals' for scaffolds may exploit the power of endogenous macrophages to aid the regeneration of engineered tissues. To realise this goal, this study devised an injectable, instantaneously-solidifying coating material (acBSP) based on a unique, macrophage-affinitive glucomannan polysaccharide. Coating of three-dimensional hydrogel constructs with acBSP was rapid, neat and complete, requiring neither chemical reactions nor harsh conditions. Comprehensive in vitro analyses indicated that acBSP efficiently facilitated the adhesion and activation of macrophages and notably induced the macrophages to express pro-osteogenic/-angiogenic genes. Further in vivo assessment of acBSP-coated, mesenchymal stem cells-laden hydrogels in a murine dorsal subcutaneous pocket model demonstrated efficient macrophage activation, desirable scaffold-tissue integration and improved osteogenic differentiation in the delivered cells. In summary, by activating macrophages into a pro-osteogenic phenotype, the acBSP coating has demonstrated its competency as an innovative, open and efficacious platform to harness the power of host immunity for enhancing the regenerative performance of engineered tissue constructs. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordBioactive Coating Glucomannan Polysaccharides Scaffold-tissue Integration Macrophages Osteogenesis
DOIhttp://doi.org/10.1016/j.biomaterials.2017.05.042
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000403564300004
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Faculty of Health Sciences
Corresponding AuthorDong, Lei; Wang, Chunming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau SAR, China
2.State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China
3.Faculty of Health Sciences, University of Macau, Avenida da Universidade, Macau SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Niu, Yiming,Li, Qiu,Xie, Ruiyu,et al. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material[J]. BIOMATERIALS,2017,139:39-55.
APA Niu, Yiming.,Li, Qiu.,Xie, Ruiyu.,Liu, Shang.,Wang, Ruibing.,...&Wang, Chunming.(2017).Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material.BIOMATERIALS,139,39-55.
MLA Niu, Yiming,et al."Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material".BIOMATERIALS 139(2017):39-55.
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