CMOS biosensors for in vitro diagnosis–transducing mechanisms and applications
Ka-Meng Lei1,2; Pui-In Mak1,2; Man-Kay Law1; Rui P. Martins1,2,3
Source PublicationLab on a Chip

Complementary metal oxide semiconductor (CMOS) technology enables low-cost and large-scale integration of transistors and physical sensing materials on tiny chips (e.g., <1 cm2), seamlessly combining the two key functions of biosensors: transducing and signal processing. Recent CMOS biosensors unified different transducing mechanisms (impedance, fluorescence, and nuclear spin) and readout electronics have demonstrated competitive sensitivity for in vitro diagnosis, such as detection of DNA (down to 10 aM), protein (down to 10 fM), or bacteria/cells (single cell). Herein, we detail the recent advances in CMOS biosensors, centering on their key principles, requisites, and applications. Together, these may contribute to the advancement of our healthcare system, which should be decentralized by broadly utilizing point-of-care diagnostic tools.

Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
WOS SubjectBiochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology
WOS IDWOS:000384467100004
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Corresponding AuthorPui-In Mak
Affiliation1.State-Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, China
2.On leave from Instituto Superior Técnico, Universidade de Lisboa, Portugal
3.Faculty of Science and Technology, Dept. of ECE, University of Macau, China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Ka-Meng Lei,Pui-In Mak,Man-Kay Law,et al. CMOS biosensors for in vitro diagnosis–transducing mechanisms and applications[J]. Lab on a Chip,2016,16(19):3664-3681.
APA Ka-Meng Lei,Pui-In Mak,Man-Kay Law,&Rui P. Martins.(2016).CMOS biosensors for in vitro diagnosis–transducing mechanisms and applications.Lab on a Chip,16(19),3664-3681.
MLA Ka-Meng Lei,et al."CMOS biosensors for in vitro diagnosis–transducing mechanisms and applications".Lab on a Chip 16.19(2016):3664-3681.
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