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Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi
Feng, Zhe-Ling; Li, Dan; Liu, Qian-Yu; Liu, Jing-Xin; Huang, Li; Zhang, Qing-Wen; Wang, Yi-Tao; Lin, Li-Gen
2017-09
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume21Pages:260-263
Abstract

In searching for naturally occurring anti-inflammatory agents, three new abietane-type diterpenoids, named 16-hydroxylambertic acid (1), 7-oxo-18-hydroxyferruginol (2), and 5 alpha, 12-dihydroxy-6-oxa-abieta-8,11,13-trien-7one (3), were isolated from the seeds of Podocarpus nagi, together with three known compounds. The structures of the new compounds were elucidated by extensive analysis of NMR and HR-ESIMS data. All the new compounds were tested for nitric oxide (NO) inhibitory activities on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Compound 1 significantly inhibited NO production with IC50 value of 5.38 +/- 0.17 mu M, and suppressed inducible NO synthase (iNOS) expression in a dose-dependent manner, which were mediated through inhibiting the mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B) activation.

KeywordPodocarpus Nagi Abietane Diterpenoids No Production Anti-inflammation
DOIhttp://doi.org/10.1016/j.phytol.2017.07.011
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000414229300051
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin, Li-Gen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Feng, Zhe-Ling,Li, Dan,Liu, Qian-Yu,et al. Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi[J]. PHYTOCHEMISTRY LETTERS,2017,21:260-263.
APA Feng, Zhe-Ling.,Li, Dan.,Liu, Qian-Yu.,Liu, Jing-Xin.,Huang, Li.,...&Lin, Li-Gen.(2017).Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi.PHYTOCHEMISTRY LETTERS,21,260-263.
MLA Feng, Zhe-Ling,et al."Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi".PHYTOCHEMISTRY LETTERS 21(2017):260-263.
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