UM  > 健康科學學院
Temporal establishment of neural cell identity in vivo and in vitro
Yuen, Shun Ming; Kwok, Hang Fai
2017-09
Source PublicationJOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
ISSN1932-6254
Volume11Issue:9Pages:2582-2589
Abstract

Understanding cell fate specification is particularly useful because it enables biologists to generate specific neural cell types for treating currently untreatable neurological diseases. Traditionally, line-age-specific progenitors are generated in vitro from pluripotent cells, after which they may be channeled into more mature cell types in a stage-specific manner, which is similar to the way cells behave during development. However, the emergence of induced pluripotent stem cells means that specific cell types can be generated directly from fibroblasts or other somatic cell types, thus bypassing all of the necessary steps that happen in vivo. Based on this information, the present review first explores the regulatory circuitry that drives cell fate specification over time in vivo. In particular, it describes how the appearance of specific neuronal and glial cell types is governed by an intrinsic biological clock, followed by a discussion of how this can be achieved through the temporal expression of intracellular regulators in relation to cell-specific Dnase I hypersensitivity sites, promoters and enhancers. Cell fate acquisition in vitro was then examined in an attempt to evaluate whether the temporal regulation neural cell fate in vivo is still relevant to the generation of reprogrammed neural stem cells and neurons. Copyright (C) 2016 John Wiley & Sons, Ltd.

KeywordTemporal Regulation Neural Stem Cells Embryonic Stem Cells Induced Pluripotent Stem Cells Cis-regulatory Elements Cell Fates Neural Specification
DOIhttps://doi.org/10.1002/term.2158
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Biotechnology & Applied Microbiology ; Engineering
WOS SubjectCell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical
WOS IDWOS:000411481600013
PublisherWILEY
The Source to ArticleWOS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai
AffiliationFaculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yuen, Shun Ming,Kwok, Hang Fai. Temporal establishment of neural cell identity in vivo and in vitro[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2017,11(9):2582-2589.
APA Yuen, Shun Ming,&Kwok, Hang Fai.(2017).Temporal establishment of neural cell identity in vivo and in vitro.JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,11(9),2582-2589.
MLA Yuen, Shun Ming,et al."Temporal establishment of neural cell identity in vivo and in vitro".JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 11.9(2017):2582-2589.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuen, Shun Ming]'s Articles
[Kwok, Hang Fai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuen, Shun Ming]'s Articles
[Kwok, Hang Fai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuen, Shun Ming]'s Articles
[Kwok, Hang Fai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.