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Adjunctive celecoxib for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials
Zheng, Wei1; Cai, Dong-Bin2; Yang, Xin-Hu1; Ungvari, Gabor S.3,4; Ng, Chee H.5; Mueller, Norbert6; Ning, Yu-Ping1; Xiang, Yu-Tao7

Neuroinflammation has been implicated in the neurobiological pathways of schizophrenia. This meta analysis evaluated the efficacy and tolerability of adjunctive celecoxib as a noncompetitive anti inflammation drug in treating schizophrenia. Data were searched, extracted, checked and entered into the RevMan (version 5.3) software by two independent investigators. Standardized/weighted mean differences (SMDs/WMDs), risk ratio (RR) and their 95% confidence intervals (Cls) were calculated, as appropriate. Included were 8 randomized controlled trials (RCTs) with a total of 626 patients with schizophrenia including 316 (50.5%) treated on celecoxib (400 mg/day) and 310 (49.5%) on placebo over 8.3 2.3 weeks of treatment. Adjunctive celecoxib outperformed placebo with respect to total psychopathology [3 RCTs, n = 180; SMD: -0.47; 95%Cl: -0.81, -0.14; P = 0.005; I-2 = 18%; 'moderate quality'], symptoms positive [3 RCTs, n = 180; SMD: -0.50; 95%CI: -0.79, 0.20; P = 0.001; I-2 = 0%; 'moderate quality], negative symptoms [3 RCTs, n = 180; SMD: 0.32; 95% CI: 0.66, 0.02; P = 0.06; = 22%; 'moderate quality'], and general psychopathology scores [3 RCTs, n = 180; SMD: 0.35; 95% CI: 0.65, 0.06; P = 0.02; I-2 = 0%; 'moderate quality'] in first-episode, but not chronic patients. Additionally, superiority of celecoxib for the Positive and Negative Syndrome Scale (PANSS) total scores was moderated by higher PANSS positive scores and lower PANSS negative scores at baseline. All-cause discontinuation [RR: 1.02; (95%Cl: 0.56,1.86); P = 0.94; I-2 = 0%] and adverse drug reactions were similar between the two groups. Adjunctive celecoxib appears to be an efficacious and safe treatment in improving psychotic symptoms, particularly in first-episode schizophrenia.

KeywordCelecoxib Schizophrenia Negative Symptom First Episode Meta-analysis
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Indexed BySCI ; SSCI ; SSCI
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000404701100018
The Source to ArticleWOS
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
2.Clinics of Chinese Medicine, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
3.The University of Notre Dame Australia, Marian Centre, Perth, Australia
4.School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia
5.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
6.Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universität München, Germany
7.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
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GB/T 7714
Zheng, Wei,Cai, Dong-Bin,Yang, Xin-Hu,et al. Adjunctive celecoxib for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2017,92:139-146.
APA Zheng, Wei.,Cai, Dong-Bin.,Yang, Xin-Hu.,Ungvari, Gabor S..,Ng, Chee H..,...&Xiang, Yu-Tao.(2017).Adjunctive celecoxib for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials.JOURNAL OF PSYCHIATRIC RESEARCH,92,139-146.
MLA Zheng, Wei,et al."Adjunctive celecoxib for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials".JOURNAL OF PSYCHIATRIC RESEARCH 92(2017):139-146.
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