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Methamphetamine abuse impairs motor cortical plasticity and function
Huang, X.1,2,3; Chen, Y-Y4; Shen, Y.5; Cao, X.6; Li, A.1,2; Liu, Q.1,2; Li, Z.7; Zhang, L-B4; Dai, W.5; Tan, T.8; Arias-Carrion, O.9; Xue, Y-X4,10; Su, H.11; Yuan, T-F1,2,3,12
2017-09
Source PublicationMOLECULAR PSYCHIATRY
ISSN1359-4184
Volume22Issue:9Pages:1274-1281
Abstract

Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain areas have not been fully investigated. Here, we characterize synaptic plasticity in motor cortex after methamphetamine self-administration in rats. We show that this causes a loss of corticostriatal plasticity in rat brain slices and impaired motor learning in the rotarod task. These findings are paralleled by the observation of a lack of transcranial magnetic stimulation-induced potentiation or depression of motor evoked potentials in human patients with addiction, along with poor performance in rotary pursuit task. Taken together, our results suggest that chronic methamphetamine use can affect behavioral performance via drug-evoked synaptic plasticity occluding physiological motor learning.

DOI10.1038/mp.2017.143
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS IDWOS:000408191000007
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorArias-Carrion, O.; Xue, Y-X; Su, H.; Yuan, T-F
Affiliation1.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2.School of Psychology, Nanjing Normal University, Nanjing, China
3.Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
4.National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China
5.Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
6.Da Lian Shan Institute of Addiction Rehabilitation, Nanjing, China
7.Cangzhou Medical College, Cangzhou, Hebei, China
8.Sichuan Provincial Hospital for Women and Children, Chengdu, China
9.Unidad de Trastornos del Movimiento y Sueno, Hospital General Dr Manuel Gea Gonzalez, Mexico City, Mexico
10.Key Laboratory for Neuroscience of Ministry of Education and Neuroscience, National Health and Family Planning Commission, Peking University, Beijing, China
11.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
12.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang, X.,Chen, Y-Y,Shen, Y.,et al. Methamphetamine abuse impairs motor cortical plasticity and function[J]. MOLECULAR PSYCHIATRY,2017,22(9):1274-1281.
APA Huang, X..,Chen, Y-Y.,Shen, Y..,Cao, X..,Li, A..,...&Yuan, T-F.(2017).Methamphetamine abuse impairs motor cortical plasticity and function.MOLECULAR PSYCHIATRY,22(9),1274-1281.
MLA Huang, X.,et al."Methamphetamine abuse impairs motor cortical plasticity and function".MOLECULAR PSYCHIATRY 22.9(2017):1274-1281.
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