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A lipid droplet-targeted fluorescence probe for visualizing exogenous copper (II) based on LLCT and LMCT
Xia, Ying1,2; Yu, Tingting1,2; Li, Fei1,2; Zhu, Weiju1,2; Ji, Yinggang1,2; Kong, Shuai1,2; Li, Chunxia3; Huang, Bei3; Zhang, Xuanjun4; Tian, Yupeng1,2; Zhou, Hongping1,2
2018-10
Source PublicationTALANTA
ISSN0039-9140
Volume188Pages:178-182
Abstract

A simple and sensitive probe, pyridine-based Schiff base (PBSB), is prepared based on the previous studies, which shows a rapid response to copper (II) through a fluorescence enhancement process. On association with copper (II), PBSB immediately presents a large red-shift (130 nm) in emission spectrum simultaneously accompanying with increasing emission intensity. The mechanism and binding sites of PBSB detecting copper (II) have been established by theoretical calculations and (HNMR)-H-1 study, respectively. More importantly, in the complex biological system, PBSB having an excellent membrane permeability and a great photostability can visualize copper (II) in lipid droplet by bio-imaging, which display so great promising advantages in the issues causing by disorder of copper ions that could be convenient for prevention and control problems with human health and complex bio-system.

KeywordFluorescence Probe Recognition Mechanism Llct And Lmct Lipid Droplet Biological Application
DOI10.1016/j.talanta.2018.05.080
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000440958700022
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
2.AnHui Prov Key Lab Chem Inorgan Organ Hybrid Func, Key Lab Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Anhui, Peoples R China
3.Anhui Univ, Ctr Stem Cell Res & Transformat Med, Hefei 230601, Anhui, Peoples R China
4.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Xia, Ying,Yu, Tingting,Li, Fei,et al. A lipid droplet-targeted fluorescence probe for visualizing exogenous copper (II) based on LLCT and LMCT[J]. TALANTA,2018,188:178-182.
APA Xia, Ying.,Yu, Tingting.,Li, Fei.,Zhu, Weiju.,Ji, Yinggang.,...&Zhou, Hongping.(2018).A lipid droplet-targeted fluorescence probe for visualizing exogenous copper (II) based on LLCT and LMCT.TALANTA,188,178-182.
MLA Xia, Ying,et al."A lipid droplet-targeted fluorescence probe for visualizing exogenous copper (II) based on LLCT and LMCT".TALANTA 188(2018):178-182.
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