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Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil
Chen, Xiao-Xin1; Leung, George Pak-Heng2; Zhang, Zhang-Jin1; Xiao, Jian-Bo3; Lao, Li-Xing1; Feng, Feng4; Mak, Judith Choi-Wo2; Wang, Ying5; Sze, Stephen Cho-Wing1; Zhang, Kahn Yan-Bo1
2017-09
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
Volume107Pages:248-260
Abstract

Breast cancer is the most frequently diagnosed cancer and cause of cancer death in women worldwide. Current treatments often result in systematic toxicity and drug resistance. Combinational use of nontoxic phytochemicals with chemotherapeutic agents to enhance the efficacy and reduce toxicity would be one promising approach. In this study, bioactive proanthocyanidins from Uncaria rhynchophylla (UPAs) were isolated and their anti-breast cancer effects alone and in combination with 5-fluorouracil (5-FU) were investigated in MDA-MB-231 breast cancer cells. The results showed that UPAs significantly inhibited cell viability and migration ability in a dose-dependent manner. Moreover, UPAs induced apoptosis in a dose-dependent manner which was associated with increased cellular reactive oxygen species production, loss of mitochondrial membrane potential, increases of Bax/Bcl-2 ratio and levels of cleaved caspase 3. Treatments of the cells with UPAs resulted in an increase in G2/M cell cycle arrest. Cytotoxic effects of 5-FU against MDA-MB-231 cells were enhanced by UPAs. The combination treatment of UPAs and 5-FU for 48 h elicited a synergistic cytotoxic effect on MDA-MB-231 cells. Altogether, these data suggest that UPAs are potential therapeutic agents for breast cancer. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordUncaria Rhynchophylla Proanthocyanidins 5-fluorouracil Breast Cancer Apoptosis
DOI10.1016/j.fct.2017.07.012
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000407982900025
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong
2.Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
3.Institute of Chinese Medical Sciences, University of Macau (UM).N22 Research Building, Avenida da Universidade, Taipa, Macau, China
4.Department of Natural Products Chemistry, Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Jiangning, China
5.Sichuan Cancer Hospital, 55 Tongzi Lin Road, Chengdu, Sichuan, China
Recommended Citation
GB/T 7714
Chen, Xiao-Xin,Leung, George Pak-Heng,Zhang, Zhang-Jin,et al. Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil[J]. FOOD AND CHEMICAL TOXICOLOGY,2017,107:248-260.
APA Chen, Xiao-Xin.,Leung, George Pak-Heng.,Zhang, Zhang-Jin.,Xiao, Jian-Bo.,Lao, Li-Xing.,...&Zhang, Kahn Yan-Bo.(2017).Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil.FOOD AND CHEMICAL TOXICOLOGY,107,248-260.
MLA Chen, Xiao-Xin,et al."Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil".FOOD AND CHEMICAL TOXICOLOGY 107(2017):248-260.
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