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Implementation of FLIM and SIFT for improved intraoperative delineation of glioblastoma margin
Lin, Danying1; Luo, Teng1; Liu, Liwei1; Lu, Yuan2; Liu, Shaoxiong3; Yuan, Zhen4; Qu, Junle1
2017-09-10
Source PublicationCHINESE OPTICS LETTERS
ISSN1671-7694
Volume15Issue:9
Abstract

The aim of this study is to develop a novel technique for improving the intraoperative margin assessment of glioblastoma by examining the total extrinsic extracellular matrix (ECM) with eosin staining using fluorescence lifetime imaging microscopy (FLIM) and scale-invariant feature transform (SIFT) descriptor analysis. Pseudo-color FLIM images obviously exhibit ECM distributions, changes in sequential sections, and different regions of interest. Meanwhile, SIFT descriptors are first utilized for the discrimination of glioblastoma margins by matching similar ECM regions and extracting keypoint orientations from FLIM images obtained from a series of continuous slices. The findings indicate that FLIM imaging with SIFT analysis of the total ECM is a promising method for improving intraoperative diagnosis of frozen and surgically excised brain specimen sections.

DOI10.3788/COL201715.090006
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000410143200006
PublisherCHINESE LASER PRESS
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
2.Department of Dermatology, The Sixth People’s Hospital of Shenzhen, Shenzhen 518052, China
3.Department of Pathology, The Sixth People’s Hospital of Shenzhen, Shenzhen 518052, China
4.Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR China
Recommended Citation
GB/T 7714
Lin, Danying,Luo, Teng,Liu, Liwei,et al. Implementation of FLIM and SIFT for improved intraoperative delineation of glioblastoma margin[J]. CHINESE OPTICS LETTERS,2017,15(9).
APA Lin, Danying.,Luo, Teng.,Liu, Liwei.,Lu, Yuan.,Liu, Shaoxiong.,...&Qu, Junle.(2017).Implementation of FLIM and SIFT for improved intraoperative delineation of glioblastoma margin.CHINESE OPTICS LETTERS,15(9).
MLA Lin, Danying,et al."Implementation of FLIM and SIFT for improved intraoperative delineation of glioblastoma margin".CHINESE OPTICS LETTERS 15.9(2017).
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