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Tablets of multi-unit pellet system for controlled drug delivery
Chen, Tongkai1; Li, Jian1; Chen, Ting2; Zheng, Ying3; Sun, Changquan Calvin1
2017-09-28
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume262Pages:222-231
Abstract

The tablet of multi-unit pellet system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic alternative to conventional immediate-release dosage forms. The main advantages of TMUPS include a) ease of swallowing and b) divisible without compromising the drug release characteristics of the individual units. TMUPS can be prepared more economically than pellet-filled capsules because of the much higher production rate of tableting process. In spite of the superiorities of TMUPS, its adoption has been challenged by manufacturing problems, such as compromised integrity of coated pellets and poor content uniformity. Herein, we provide an updated review on research, from both scientific literatures and patents, related to the compaction of TMUPS. Factors important for the successful production of TMUPS are summarized, including model drug property, potential cushioning agents, and novel techniques to protect pellets from damage. This review is intended to facilitate the future development of manufacturable TMUPS with drug release behavior similar to that of the original coated pellets.

KeywordMulti-unit Pellet System (Mups) Pellets Coating Cushioning Agents Tableting Of Pellets Drug Delivery System (Dds)
DOI10.1016/j.jconrel.2017.07.043
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000411201100022
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
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被引频次[WOS]:13   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Zhitong Laboratories Co., Ltd, Shanghai, China
3.Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Chen, Tongkai,Li, Jian,Chen, Ting,et al. Tablets of multi-unit pellet system for controlled drug delivery[J]. JOURNAL OF CONTROLLED RELEASE,2017,262:222-231.
APA Chen, Tongkai,Li, Jian,Chen, Ting,Zheng, Ying,&Sun, Changquan Calvin.(2017).Tablets of multi-unit pellet system for controlled drug delivery.JOURNAL OF CONTROLLED RELEASE,262,222-231.
MLA Chen, Tongkai,et al."Tablets of multi-unit pellet system for controlled drug delivery".JOURNAL OF CONTROLLED RELEASE 262(2017):222-231.
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