UM  > Institute of Chinese Medical Sciences
Tablets of multi-unit pellet system for controlled drug delivery
Chen, Tongkai1; Li, Jian1; Chen, Ting2; Zheng, Ying3; Sun, Changquan Calvin1

The tablet of multi-unit pellet system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic alternative to conventional immediate-release dosage forms. The main advantages of TMUPS include a) ease of swallowing and b) divisible without compromising the drug release characteristics of the individual units. TMUPS can be prepared more economically than pellet-filled capsules because of the much higher production rate of tableting process. In spite of the superiorities of TMUPS, its adoption has been challenged by manufacturing problems, such as compromised integrity of coated pellets and poor content uniformity. Herein, we provide an updated review on research, from both scientific literatures and patents, related to the compaction of TMUPS. Factors important for the successful production of TMUPS are summarized, including model drug property, potential cushioning agents, and novel techniques to protect pellets from damage. This review is intended to facilitate the future development of manufacturable TMUPS with drug release behavior similar to that of the original coated pellets.

KeywordMulti-unit Pellet System (Mups) Pellets Coating Cushioning Agents Tableting Of Pellets Drug Delivery System (Dds)
URLView the original
Indexed BySCI
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000411201100022
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Zhitong Laboratories Co., Ltd, Shanghai, China
3.Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Tongkai,Li, Jian,Chen, Ting,et al. Tablets of multi-unit pellet system for controlled drug delivery[J]. JOURNAL OF CONTROLLED RELEASE,2017,262:222-231.
APA Chen, Tongkai,Li, Jian,Chen, Ting,Zheng, Ying,&Sun, Changquan Calvin.(2017).Tablets of multi-unit pellet system for controlled drug delivery.JOURNAL OF CONTROLLED RELEASE,262,222-231.
MLA Chen, Tongkai,et al."Tablets of multi-unit pellet system for controlled drug delivery".JOURNAL OF CONTROLLED RELEASE 262(2017):222-231.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Tongkai]'s Articles
[Li, Jian]'s Articles
[Chen, Ting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Tongkai]'s Articles
[Li, Jian]'s Articles
[Chen, Ting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Tongkai]'s Articles
[Li, Jian]'s Articles
[Chen, Ting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.