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Luteolin exerted less inhibitory effect on macrophage activation induced by Astragalus polysaccharide than by lipopolysaccharide
Li, Zhi-Peng1; Zhang, Quan-Wei1; Wei, Wei1; Li, Li-Feng1; Ma, Dik-Lung2; Leung, Chung-Hang3; Lu, Ai-Ping1; Bian, Zhao-Xiang1; Han, Quan-Bin1
2017-10
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume37Pages:618-623
Abstract

As a kind of food supplementary, polysaccharide-rich tonic herbs become more and more popular. However, little is known regarding the interaction between known active molecules with these polysaccharides. This study aims to investigate effects of luteolin on RAW264.7 cells induced by Astragalus polysaccharide RAP in comparison with lipopolysaccharide (LPS). The results showed that luteolin suppressed inflammatory meditors in LPS-induced RAW264.7 cells. While in the RAP-induced RAW264.7 cells, luteolin only decreased the NO production and iNOS gene expression, but only inhibit IL-6 at high concentration, and was ineffective in term of TNF-alpha. The results of western blot analysis suggested that luteolin only inhibited the phosphorylation of NF-kappa B p65 and Akt, but not MAPKs and 1RF3 in RAP-induced RAW264.7 cells. Taken together, lutelion exerted less inhibitory effect on macrophage induced by RAP than by LPS. This study demonstrated the luteolin-containing foods may not strongly interfere the immunoregulation effect of polysaccharide RAP. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordAstragalus Polysaccharide Luteolin Raw264.7 Mapks Nf-kappa b
DOI10.1016/j.jff.2017.08.023
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000412863400063
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhi-Peng,Zhang, Quan-Wei,Wei, Wei,et al. Luteolin exerted less inhibitory effect on macrophage activation induced by Astragalus polysaccharide than by lipopolysaccharide[J]. JOURNAL OF FUNCTIONAL FOODS,2017,37:618-623.
APA Li, Zhi-Peng.,Zhang, Quan-Wei.,Wei, Wei.,Li, Li-Feng.,Ma, Dik-Lung.,...&Han, Quan-Bin.(2017).Luteolin exerted less inhibitory effect on macrophage activation induced by Astragalus polysaccharide than by lipopolysaccharide.JOURNAL OF FUNCTIONAL FOODS,37,618-623.
MLA Li, Zhi-Peng,et al."Luteolin exerted less inhibitory effect on macrophage activation induced by Astragalus polysaccharide than by lipopolysaccharide".JOURNAL OF FUNCTIONAL FOODS 37(2017):618-623.
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