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Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells
Wu, Zheng-Feng1,2; Meng, Fan-Cheng1,3; Cao, Lan-Jie1,2; Jiang, Cui-Hua2; Zhao, Meng-Ge1,2; Shang, Xu-Lan4; Fang, Sheng-Zuo4; Ye, Wen-Cai5; Zhang, Qing-Wen3; Zhang, Jian2; Yin, Zhi-Qi1
2017-10
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume142Pages:76-84
Abstract

Five previously undescribed compounds including two triterpenoid aglycones, 3 beta,23-dihydroxy-1,12-dioxo-olean-28-oic acid and 3 beta,23,27-trihydroxy-1-oxo-olean-12-ene-28-oic acid, and three triterpenoid glucosides cyclocarioside L-N, along with 17 known compounds were isolated from a CH3Cl-soluble extract of the leaves of Cyclocarya paliurus. Two 27-nor-triterpenoid glycosides were isolated from the genus for the first time. Furthermore, the characterized compounds were tested for the inhibitory effects on apoliprotein B48 secretion in Caco-2 cells. Seven triterpenoid aglycones together with four triterpenoid saponins significantly decreased the apoliprotein B48 oversecretion induced by oleic acid in Caco-2 cells. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordCyclocarya Paliurus Juglandaceae Triterpenoids Cyclocarioside Apoliprotein B48
DOI10.1016/j.phytochem.2017.06.015
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000408784800009
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China
2.Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, PR China
3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, PR China
4.College of Forestry, Nanjing Forestry University, Nanjing, 210037, PR China
5.Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, PR China
Recommended Citation
GB/T 7714
Wu, Zheng-Feng,Meng, Fan-Cheng,Cao, Lan-Jie,et al. Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells[J]. PHYTOCHEMISTRY,2017,142:76-84.
APA Wu, Zheng-Feng.,Meng, Fan-Cheng.,Cao, Lan-Jie.,Jiang, Cui-Hua.,Zhao, Meng-Ge.,...&Yin, Zhi-Qi.(2017).Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells.PHYTOCHEMISTRY,142,76-84.
MLA Wu, Zheng-Feng,et al."Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells".PHYTOCHEMISTRY 142(2017):76-84.
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