UM
Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia
Cheung, David Wing-Shing; Koon, Chi-Man; Wong, Pui-Han; Yau, Ka-Chun; Wat, Elaine; Hung, Angela Sze-Man; Wang, Yan-Ping; Lau, Kit-Man; Ko, Chun-Hay; Chan, Judy Yuet-Wa; Waye, Mary Miu-Yee; Fung, Kwok-Pui
2017-10
Source PublicationPHYTOTHERAPY RESEARCH
ISSN0951-418X
Volume31Issue:10Pages:1579-1589
AbstractDespite being a potent hypolipidemic drug, atorvastatin (AS) possesses certain adverse effects. Using AS and an herbal formula (Danshen and Gegen, DG) in combination may achieve potentiated hypolipidemic effects and also reduce its adverse effects. Hence, this study aimed to investigate the efficacy and safety of an AS and DG combination on high-fat diet-induced hyperlipidemia. Treatment outcomes were assessed by measuring parameters including body weight, adipose tissue, liver, total cholesterol, triglyceride, and low-density and high-density lipoprotein cholesterol. Measurements of adverse effects were achieved by determining aspartate aminotransferase (AST), alanine transaminase (ALT), and creatine kinase (CK). Danshen and Gegen, as well as AS alone, reduced body weight, adipose tissue, liver weight, liver fat vacuoles, total liver lipids, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in high-fat diet-fed mice but increased AST, ALT, and CK. A combination of AS and DG was able to enhance reduced effects on the aforementioned parameters in relation to hyperlipidemia over AS or DG alone. It also reduced the elevation of AST, ALT, and CK induced than by AS or DG alone. Results demonstrated that an AS and DG combination resulted in stronger hypolipidemic effects than with AS or DG alone. Additionally, DG might attenuate adverse effects of AS on the liver and skeletal muscle. Copyright (C) 2017 John Wiley & Sons, Ltd.
Keywordhyperlipidemia herbal medicine Danshen Gegen atorvastatin herb-drug interaction
DOI10.1002/ptr.5888
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000412164200013
PublisherWILEY
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Cheung, David Wing-Shing,Koon, Chi-Man,Wong, Pui-Han,et al. Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia[J]. PHYTOTHERAPY RESEARCH,2017,31(10):1579-1589.
APA Cheung, David Wing-Shing.,Koon, Chi-Man.,Wong, Pui-Han.,Yau, Ka-Chun.,Wat, Elaine.,...&Fung, Kwok-Pui.(2017).Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia.PHYTOTHERAPY RESEARCH,31(10),1579-1589.
MLA Cheung, David Wing-Shing,et al."Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia".PHYTOTHERAPY RESEARCH 31.10(2017):1579-1589.
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