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Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging
Wang S.2; Liu Z.2; Zou Y.2; Lai X.2; Ding D.2; Chen L.1; Zhang L.2; Wu Y.2; Chen Z.2; Tan W.2
2016-06-07
Source PublicationAnalyst
ISSN13645528 00032654
Volume141Issue:11Pages:3337-3342
Abstract

Elucidating the endocytosis and metabolism of nanoparticles in cells could improve the diagnostic sensitivity and therapeutic efficiency. In this work, we explore the cellular uptake mechanism of a biocompatible nanocrystal nanostructure, graphene-isolated-Au-nanocrystals (GIANs), by monitoring the intrinsic Raman and two-photon luminescence signals of GIANs in live cells. Aptamers functionalized on the GIAN nanostructure through simple, but strong, π-π interactions entered the cells through a clathrin-dependent pathway, while unmodified GIANs mainly entered the cells through a caveolae-mediated endocytosis pathway. Thus, it can be concluded that the mechanism of cellular uptake in these graphene-isolated-Au-nanocrystal nanostructures is determined by the presence or absence of aptamer modification.

DOI10.1039/c6an00483k
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000377225600023
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF COMPUTER AND INFORMATION SCIENCE
Affiliation1.Universidade de Macau
2.Hunan University
3.University of Florida
Recommended Citation
GB/T 7714
Wang S.,Liu Z.,Zou Y.,et al. Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging[J]. Analyst,2016,141(11):3337-3342.
APA Wang S..,Liu Z..,Zou Y..,Lai X..,Ding D..,...&Tan W..(2016).Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging.Analyst,141(11),3337-3342.
MLA Wang S.,et al."Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging".Analyst 141.11(2016):3337-3342.
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