UM
Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules
Dong Q.1; Wang X.1; Hu X.1; Xiao L.1; Zhang L.1; Song L.1; Xu M.1; Zou Y.1; Chen L.2; Chen Z.1; Tan W.1
2018-01-02
Source PublicationAngewandte Chemie - International Edition
ISSN15213773 14337851
Volume57Issue:1Pages:177-181
AbstractPhotothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene–aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π–π interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.
Keywordaspirin graphitic nanocapsules inflammation photothermal therapy prodrugs
DOI10.1002/anie.201709648
URLView the original
Language英語
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hunan University
2.Universidade de Macau
3.University of Florida
Recommended Citation
GB/T 7714
Dong Q.,Wang X.,Hu X.,et al. Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules[J]. Angewandte Chemie - International Edition,2018,57(1):177-181.
APA Dong Q..,Wang X..,Hu X..,Xiao L..,Zhang L..,...&Tan W..(2018).Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules.Angewandte Chemie - International Edition,57(1),177-181.
MLA Dong Q.,et al."Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules".Angewandte Chemie - International Edition 57.1(2018):177-181.
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