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Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-kappa B signaling pathway
Li, Min; Chen, Ling-Xiao; Chen, Shao-Ru; Deng, Yong; Zhao, Jing; Wang, Ying; Li, Shao-Ping
2017-10
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume37Pages:491-500
AbstractA non-starch polysaccharide (NSCYP) isolated and purified from Chinese yam (Dioscorea opposita Thunb.) with its immunomodulatory activities on RAW 264.7 macrophages in vitro was reported. Chemical studies showed that the average molecular weight was 71.78 kDa. NSCYP was mainly composed of mannose, galacturonic acid, glucose, galactose, and arabinose with a molar ratio of 1.09:0.51:1.0:3.03:1.77. Moreover, t-Araf, 1,5-Araf, t-Glcp, t-Galp, t-GalAp, t-Ga1MEp, 1,4-Galp, 1,4-GalAp, 1,4-GaIMEp, 1,4-Glcp, 1,6-Galp, 4,6-Galp and 4,6-Manp were detected in NSCYP. NSCYP promoted RAW 264.7 macrophages phagocytic activity, NO release, transcription and production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. NSCYP induced NF-kappa B activation and I kappa B alpha degradation in RAW 264.7 cells. Notably, inhibition of Toll-like receptor 4 led to the suppression of NSCYP-induced NO production in RAW 264.7 cells. These findings suggested that NSCYP exhibit the potential as functional food or therapeutic stimulant as a natural immune-stimulating polysaccharide. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordNon-starch polysaccharide Chinese yam RAW 264.7 macrophages Immunogenic activity NF-kappa B singling Toll-like receptor 4
DOI10.1016/j.jff.2017.08.025
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000412863400049
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Li, Min,Chen, Ling-Xiao,Chen, Shao-Ru,et al. Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-kappa B signaling pathway[J]. JOURNAL OF FUNCTIONAL FOODS,2017,37:491-500.
APA Li, Min.,Chen, Ling-Xiao.,Chen, Shao-Ru.,Deng, Yong.,Zhao, Jing.,...&Li, Shao-Ping.(2017).Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-kappa B signaling pathway.JOURNAL OF FUNCTIONAL FOODS,37,491-500.
MLA Li, Min,et al."Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-kappa B signaling pathway".JOURNAL OF FUNCTIONAL FOODS 37(2017):491-500.
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