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Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing
Ma, Dik-Lung; Dong, Zhen-Zhen; Vellaisamy, Kasipandi; Cheung, Ka-Man; Yang, Guanjun; Leung, Chung-Hang
2017-11
Source PublicationCHEMICAL RECORD
ISSN1527-8999
Volume17Issue:11Pages:1135-1145
AbstractBy catalyzing highly specific and tightly controlled chemical reactions, enzymes are essential to maintaining normal cellular physiology. However, aberrant enzymatic activity can be linked to the pathogenesis of various diseases. Therefore, the unusual activity of particular enzymes can represent testable biomarkers for the diagnosis or screening of certain diseases. In recent years, G-quadruplex-based platforms have attracted wide attention for the monitoring of enzymatic activities. In this Personal Account, we discuss our group's works on the development of G-quadruplex-based sensing system for enzyme activities by using mainly iridium(III) complexes as luminescent label-free probes. These studies showcase the versatility of the G-quadruplex for developing assays for a variety of different enzymes.
KeywordG-quadruplex enzyme iridium(III) complex luminescent enhancement
DOI10.1002/tcr.201700014
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000417501300005
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
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Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Ma, Dik-Lung,Dong, Zhen-Zhen,Vellaisamy, Kasipandi,et al. Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing[J]. CHEMICAL RECORD,2017,17(11):1135-1145.
APA Ma, Dik-Lung,Dong, Zhen-Zhen,Vellaisamy, Kasipandi,Cheung, Ka-Man,Yang, Guanjun,&Leung, Chung-Hang.(2017).Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing.CHEMICAL RECORD,17(11),1135-1145.
MLA Ma, Dik-Lung,et al."Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing".CHEMICAL RECORD 17.11(2017):1135-1145.
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