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Characterization and immunoregulatory activity of two polysaccharides from the root of Ilex asprella
Meng, Fancheng1; Li, Qiu1; Qi, Yaning2; He, Chengwei1; Wang, Chunming1; Zhang, Qingwen1
2018-10
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume197Pages:9-16
Abstract

The polysaccharides obtained from the root of Ilex asprella, namely IAPS-1 and IAPS-2, with immunoregulatory activity were studied. Two polysaccharides were isolated and purified by Cellulose DEAE-52 and Sephadex columns. The structure of IAPS-1 was elucidated as 1,6-linked alpha-D-glucopyranosyl main chain with branch chain substituted at C-2 and/or C-4 position. For IAPS-2, the backbone is composed of 1, 4-linked alpha-D-glucose, galactose and rhamnose, and branched chains consists of arabinose, rhamnose and galacturonic acid, as confirmed by partial acid hydrolysis and NMR study. Further, the immunoregulatory activity of IAPS-1 and IAPS-2 was tested with the murine macrophages. Particularly, IAPS-2 polysaccharide can more effectively enhance the secretion of major inflammatory cytokines in macrophages, such as TNF-alpha, IL-1 beta, IL-12, compared with IAPS-1.

KeywordIlex Asprella Polysaccharide Structure Immunoregulatory
DOI10.1016/j.carbpol.2018.05.066
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000438466500002
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMeng, Fancheng; Li, Qiu; Qi, Yaning; He, Chengwei; Wang, Chunming; Zhang, Qingwen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.Choi Kai Yau College, University of Macau, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Recommended Citation
GB/T 7714
Meng, Fancheng,Li, Qiu,Qi, Yaning,et al. Characterization and immunoregulatory activity of two polysaccharides from the root of Ilex asprella[J]. CARBOHYDRATE POLYMERS,2018,197:9-16.
APA Meng, Fancheng,Li, Qiu,Qi, Yaning,He, Chengwei,Wang, Chunming,&Zhang, Qingwen.(2018).Characterization and immunoregulatory activity of two polysaccharides from the root of Ilex asprella.CARBOHYDRATE POLYMERS,197,9-16.
MLA Meng, Fancheng,et al."Characterization and immunoregulatory activity of two polysaccharides from the root of Ilex asprella".CARBOHYDRATE POLYMERS 197(2018):9-16.
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