UM
Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy
Liu, Jingjing; Yang, Guangbao; Zhu, Wenwen; Dong, Ziliang; Yang, Yu; Chao, Yu; Liu, Zhuang
2017-11
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume146Pages:40-48
AbstractThe development of smart drug delivery systems to realize controlled drug release for highly specific cancer treatment has attracted tremendous attention. Herein, nanoscale coordination polymers (NCPs) constructed from hafnium ions and bis-(alkylthio) alkene (BATA), a singlet-oxygen responsive linker, are fabricated and applied as nanocarriers to realize light-controlled drug release under a rather low optical power density. In this system, NCPs synthesized through a solvothermal method are sequentially loaded with chlorin e6 (Ce6), a photosensitizer, and doxorubicin (DOX), a chemotherapeutic drug, and then coated with lipid bilayer to allow modification with polyethylene glycol (PEG) to acquire excellent colloidal stability. The singlet oxygen produced by such NCP-Ce6-DOX-PEG nanocomposite can be used not only for photodynamic therapy, but also to induce the break of BATA linker and thus the destruction of nanoparticle structures under light exposure, thereby triggering effective drug release. Notably, with efficient tumor accumulation after intravenous injection as revealed by CT imaging, those NCP-Ce6-DOX-PEG nanoparticles could be utilized for combined chemo-photodynamic therapy with great antitumor efficacy. Thus, this work presents a unique type of NCP-based drug delivery system with biodegradability, sensitive responses to light, as well as highly efficient tumor retention for effective cancer combinational treatment. (C) 2017 Elsevier Ltd. All rights reserved..
KeywordNanoscale coordinate polymers Drug delivery Light-responsive release Combination therapy CT imaging
DOI10.1016/j.biomaterials.2017.09.007
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000412958000004
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Liu, Jingjing,Yang, Guangbao,Zhu, Wenwen,et al. Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy[J]. BIOMATERIALS,2017,146:40-48.
APA Liu, Jingjing.,Yang, Guangbao.,Zhu, Wenwen.,Dong, Ziliang.,Yang, Yu.,...&Liu, Zhuang.(2017).Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy.BIOMATERIALS,146,40-48.
MLA Liu, Jingjing,et al."Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy".BIOMATERIALS 146(2017):40-48.
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