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An iridium(III) complex-based chemosensor for the detection of thiourea in living cells
Wang, Wanhe; Dong, Zhen-Zhen; Yang, Chao; Li, Guodong; Tse, Yam-Chi; Leung, Chung-Hang; Ma, Dik-Lung
2017-11
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume251Pages:374-379
AbstractThe adverse effects that thiourea can induce in biological systems demand the development of new methods for its detection. In this work, we present a iridium(III) complex-based chemosensor (1) containing a recognition unit for thiourea. The reaction of the recognition unit with thiourea affects the long-lived excited states of the complex, leading to an enhancement of luminescence. Complex 1 showed a 3.3-fold enhanced luminescence in the presence of thiorea and a good linear relationship with thiourea ranging from 10 to 200 mu M, with a limit of detection (LOD) of 3.85 mu M. By using time-resolved emission spectroscopy (TRES), complex 1 could detect thiourea in the presence of interfering fluorescence. Moreover, complex 1 offers the capability to image thiourea in living HeLa cells. To our knowledge, complex 1 is the first iridium(III) complex-based sensor reported for imaging thiourea in living cells. (C) 2017 Elsevier B.V. All rights reserved.
KeywordIridium(III) complex Chemosensor Luminescence Thiourea
DOI10.1016/j.snb.2017.05.100
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000406184600045
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Wanhe,Dong, Zhen-Zhen,Yang, Chao,et al. An iridium(III) complex-based chemosensor for the detection of thiourea in living cells[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,251:374-379.
APA Wang, Wanhe.,Dong, Zhen-Zhen.,Yang, Chao.,Li, Guodong.,Tse, Yam-Chi.,...&Ma, Dik-Lung.(2017).An iridium(III) complex-based chemosensor for the detection of thiourea in living cells.SENSORS AND ACTUATORS B-CHEMICAL,251,374-379.
MLA Wang, Wanhe,et al."An iridium(III) complex-based chemosensor for the detection of thiourea in living cells".SENSORS AND ACTUATORS B-CHEMICAL 251(2017):374-379.
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