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Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier
Li, Ye1; Chen, Tongkai1; Miao, Xiaoqing1; Yi, Xiang2; Wang, Xueqing3; Zhao, Haitao4; Lee, Simon Ming-Yuen1; Zheng, Ying1
2017-11
Source PublicationPHARMACOLOGICAL RESEARCH
ISSN1043-6618
Volume125Pages:246-257
Abstract

The blood brain barrier (BBB) is the network of capillaries that controls the passage of substances from the blood into the brain and other parts of the central nervous system (CNS). As this barrier is the major obstacle for drug delivery into CNS, a credible BBB model is very necessary to assess the BBB permeability of novel neuroactive compounds including thousands of bioactive compounds which have been extracted from medicinal plants and have the potential for the treatment of CNS diseases. Increasing reports indicated that zebrafish has emerged as a timely, reproducible model for BBB permeability assessment. In this review, the development and functions of the BBB in zebrafish, such as its anatomical morphology, tight junctions, drug transporters and enzyme expression, are compared with those in mammals. The studies outlined in this review describe the utilization of the zebrafish as a BBB model to investigate the permeability and distribution of fluorescent dyes and drugs. Particularly, this review focuses on the use of zebrafish to evaluate the delivery of natural products and nanosized drug delivery systems across the BBB. Due to the highly conserved nature of both the structure and function of the BBB between zebrafish and mammals, zebrafish has the potential to be developed as a model for assessing and predicting the permeability of BBB to novel compounds. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordBlood Brain Barrier (Bbb) Zebrafish Fluorescence Dyes Natural Products Drug Delivery Systems Permeability
DOI10.1016/j.phrs.2017.08.017
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000414110400014
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA
3.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
4.Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Ye,Chen, Tongkai,Miao, Xiaoqing,et al. Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier[J]. PHARMACOLOGICAL RESEARCH,2017,125:246-257.
APA Li, Ye.,Chen, Tongkai.,Miao, Xiaoqing.,Yi, Xiang.,Wang, Xueqing.,...&Zheng, Ying.(2017).Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier.PHARMACOLOGICAL RESEARCH,125,246-257.
MLA Li, Ye,et al."Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier".PHARMACOLOGICAL RESEARCH 125(2017):246-257.
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