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Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012)
Su, Yun-Ai1; Yan, Feng2; Li, Qian1; Xiang, Yu-Tao3; Shu, Liang1; Yu, Xin1; Ning, Yu-Ping4; Zhang, Ke-Rang5; Li, Tao6; Mei, Qi-Yi7; Li, Ke-Qing8; Si, Tian-Mei9
2017-11
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume257Pages:132-136
Abstract

Our previous study demonstrated that there have been changes in the patterns of prescription antipsychotic use in China over the period from 2002 to 2012. The aim of this study was to evaluate whether time trends were present for the prescription of anticholinergic medications (ACMs) during the observation period. A total of 14,013 patients with schizophrenia treated in 45 psychiatric hospitals/centers nationwide were surveyed in 2002, 2006 and 2012. Basic socio-demographic and clinical characteristics and the prescription of psychotropic drugs were recorded using a standardized protocol and data collection procedure. The frequency of ACM prescription was 25.9% in the whole sample (29.5%, 21.6%, and 27.4% in 2002, 2006 and 2012, respectively). In addition, different temporal trends were observed across age groups. Multiple logistic regression analysis of the entire sample showed that ACM prescriptions were predicted by females, outpatients, patients receiving high doses of antipsychotic medication, select study years, benzodiazepine users, patients displaying extrapyramidal side effects, as well as antipsychotic prescription patterns. Although there was more widespread use of second generation antipsychotics over the past decade, the frequency of ACM use only slightly decreased. How to use ACM appropriately is still a therapeutic issue that needs to foster evidence-based prescription practice.

KeywordSchizophrenia Prescription Patterns Anticholinergic Medication Extrapyramidal Symptoms
DOIhttp://doi.org/10.1016/j.psychres.2017.07.038
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000413385300022
PublisherELSEVIER IRELAND LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSi, Tian-Mei
Affiliation1.Peking University Sixth Hospital (Institute of Mental Health) & National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China
2.Peking University Sixth Hospital (Institute of Mental Health) & National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China; Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China
3.The National Clinical Research Center for Mental Disorders, China & Center of Depression, Beijing Institute for Brain Disorders & Beijing Anding Hospital, Capital Medical University, Beijing, China; Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
4.Psychiatric Hospital, Guangzhou, China
5.The First Hospital of Shanxi Medical University, Shanxi province, China.
6.West China Hospital, Sichuan University, China.
7.Suzhou Guangji Hospital, Suzhou, China.
8.Hebei Mental Health Center, Hebei, China.
9.Peking University Sixth Hospital (Institute of Mental Health) & National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China
Recommended Citation
GB/T 7714
Su, Yun-Ai,Yan, Feng,Li, Qian,et al. Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012)[J]. PSYCHIATRY RESEARCH,2017,257:132-136.
APA Su, Yun-Ai.,Yan, Feng.,Li, Qian.,Xiang, Yu-Tao.,Shu, Liang.,...&Si, Tian-Mei.(2017).Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012).PSYCHIATRY RESEARCH,257,132-136.
MLA Su, Yun-Ai,et al."Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012)".PSYCHIATRY RESEARCH 257(2017):132-136.
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