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Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation
Shi, Zhe1; Ren, Huixia1; Huang, Zhijian1; Peng, Yu1; He, Baixuan2; Yao, Xiaoli2; Yuan, Ti-Fei3; Su, Huanxing1
2017-11
Source PublicationMOLECULAR NEUROBIOLOGY
ISSN0893-7648
Volume54Issue:9Pages:7327-7334
Abstract

Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression.

KeywordFish Oil Neuroinflammation Depression Lps Hpa Axis
DOI10.1007/s12035-016-0212-9
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000412030500052
PublisherSPRINGER
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYao, Xiaoli; Yuan, Ti-Fei; Su, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical SciencesUniversity of MacauMacaoChina
2.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina
3.School of PsychologyNanjing Normal UniversityNanjingChina
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shi, Zhe,Ren, Huixia,Huang, Zhijian,et al. Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation[J]. MOLECULAR NEUROBIOLOGY,2017,54(9):7327-7334.
APA Shi, Zhe.,Ren, Huixia.,Huang, Zhijian.,Peng, Yu.,He, Baixuan.,...&Su, Huanxing.(2017).Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation.MOLECULAR NEUROBIOLOGY,54(9),7327-7334.
MLA Shi, Zhe,et al."Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation".MOLECULAR NEUROBIOLOGY 54.9(2017):7327-7334.
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