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Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia
Luo, Chuanming1; Liang, Fengyin2; Ren, Huixia1; Yao, Xiaoli2; Liu, Qiang1; Li, Mingyue2; Qin, Dajiang3; Yuan, Ti-Fei4; Pei, Zhong2; Su, Huanxing1
2017-11
Source PublicationBRAIN PATHOLOGY
ISSN1015-6305
Volume27Issue:6Pages:809-821
Abstract

Collateral blood flow as vascular adaptions to focal cerebral ischemia is well recognized. However, few studies directly investigate the dynamics of collateral vessel recruitment in vivo and little is known about the effect of collateral blood flow in different cerebrovascular hierarchy on the neuropathology after focal ischemic stroke. Here, we report that collateral blood flow is critically involved in blood vessel compensations following regional ischemia. We occluded a pial arteriole using femtosecond laser ablating under the intact thinned skull and documented the changes of collateral flow around the surface communication network and between the surface communication network and subsurface microcirculation network using in vivo two photon microscopy imaging. Occlusion of the pial arteriole apparently increased the diameter and collateral blood flow of its leptomeningeal anastomoses, which significantly reduced the cortical infarction size. This result suggests that the collateral flow via surface communicating network connected with leptomeningeal anastomoses could greatly impact on the extent of infarction. We then further occluded the target pial arteriole and all of its leptomeningeal anastomoses. Notably, this type of occlusion led to reversals of blood flow in the penetrating arterioles mainly proximal to the occluded pial arteriole in a direction from the subsurface microcirculation network to surface arterioles. Interesting, the cell death in the area of ischemic penumbra was accelerated when we performed occlusion to cease the reversed blood flow in those penetrating arterioles, suggesting that the collateral blood flow from subsurface microcirculation network exerts protective roles in delaying cell death in the ischemic penumbra. In conclusion, we provide the first experimental evidence that collateral blood vessels at different cerebrovascular hierarchy are endogenously compensatory mechanisms in brain ischemia.

KeywordCollateral Blood Flow Leptomeningeal Anastomoses Microcirculation Focal Ischemia Endogenous Protection Two-photon Microscopys
DOI10.1111/bpa.12458
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Pathology
WOS SubjectClinical Neurology ; Neurosciences ; Pathology
WOS IDWOS:000415705000008
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorPei, Zhong; Su, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
2.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, First Affiliated Hospital Sun Yat-Sen University,Guangzhou, 510080, China.
3.South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy ofSciences, Guangzhou, China.
4.School of Psychology, Nanjing Normal University, Nanjing, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Luo, Chuanming,Liang, Fengyin,Ren, Huixia,et al. Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia[J]. BRAIN PATHOLOGY,2017,27(6):809-821.
APA Luo, Chuanming.,Liang, Fengyin.,Ren, Huixia.,Yao, Xiaoli.,Liu, Qiang.,...&Su, Huanxing.(2017).Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia.BRAIN PATHOLOGY,27(6),809-821.
MLA Luo, Chuanming,et al."Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia".BRAIN PATHOLOGY 27.6(2017):809-821.
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