UM
Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism
Xiao, Cuiying; Pinol, Ramon A.; Carlin, Jesse Lea; Li, Cuiling; Deng, Chuxia; Gavrilova, Oksana; Reitman, Marc L.
2017-11
Source PublicationMOLECULAR METABOLISM
ISSN2212-8778
Volume6Issue:11Pages:1540-1550
AbstractObjective: Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor. Brs3 null mice have reduced resting metabolic rate and body temperature, increased food intake, and obesity. Here we study the role of Brs3 in different neuron types. Methods: Mice able to undergo Cre recombinase-dependent inactivation or re-expression of Brs3 were generated, respectively Brs3(fl/y) and Brs3(IoxTB/Y). We then studied four groups of mice with Brs3 selectively inactivated or re-expressed in cells expressing Vglut2-Cre or Vgat-Cre. Results: Deletion of Brs3 in glutamatergic neurons expressing Vglut2 reproduced the global null phenotype for regulation of food intake, metabolic rate, body temperature, adiposity, and insulin resistance. These mice also no longer responded to a BRS-3 agonist, MK-5046. In contrast, deletion of Brs3 in GABAergic neurons produced no detectable phenotype. Conversely, the wild type phenotype was restored by selective re-expression of Brs3 in glutamatergic neurons, with no normalization achieved by re-expressing Brs3 in GABAergic neurons. Conclusions: Brs3 expression in glutamatergic neurons is both necessary and sufficient for full Brs3 function in energy metabolism. In these experiments, no function was identified for Brs3 in GABAergic neurons. The data suggest that the anti-obesity pharmacologic actions of BRS-3 agonists occur via agonism of receptors on glutamatergic neurons. Published by Elsevier GmbH.
KeywordBombesin-like receptor 3 Obesity Energy expenditure Food intake Glutamatergic neurons Body temperature
DOI10.1016/j.molmet.2017.08.013
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000419084000018
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Xiao, Cuiying,Pinol, Ramon A.,Carlin, Jesse Lea,et al. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism[J]. MOLECULAR METABOLISM,2017,6(11):1540-1550.
APA Xiao, Cuiying.,Pinol, Ramon A..,Carlin, Jesse Lea.,Li, Cuiling.,Deng, Chuxia.,...&Reitman, Marc L..(2017).Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.MOLECULAR METABOLISM,6(11),1540-1550.
MLA Xiao, Cuiying,et al."Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism".MOLECULAR METABOLISM 6.11(2017):1540-1550.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiao, Cuiying]'s Articles
[Pinol, Ramon A.]'s Articles
[Carlin, Jesse Lea]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiao, Cuiying]'s Articles
[Pinol, Ramon A.]'s Articles
[Carlin, Jesse Lea]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiao, Cuiying]'s Articles
[Pinol, Ramon A.]'s Articles
[Carlin, Jesse Lea]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.