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Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy
Chen, Haobin1,2; Zhang, Jian3; Chang, Kaiwen2,3; Men, Xiaoju1,2; Fang, Xiaofeng2; Zhou, Libo1; Li, Dongliang3; Gao, Duyang3; Yin, Shengyan1; Zhang, Xuanjun3; Yuan, Zhen3; Wu, Changfeng2
2017-11
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume144Pages:42-52
Abstract

Semiconducting polymers with specific absorption are useful in various applications, including organic optoelectronics, optical imaging, and nanomedicine. However, the optical absorption of a semi-conducting polymer with a determined structure is hardly tunable when compared with that of inorganic semiconductors. In this work, we show that the optical absorption of polymer nanoparticles from one conjugated backbone can be effectively tuned through judicious design of the particle morphology and the persistence length of polymers. Highly absorbing near-infrared (NIR) polymers based on diketopyrrolopyrrole-dithiophene (DPP-DT) are synthesized to have different molecular weights (MWs). The DPP-DT polymer with a large molecular weight and high persistence length exhibited remarkably high optical absorption with a peak mass extinction coefficient of 81.7 L g(-1) cm(-1), which is one of the highest value among various photothermal agents reported to date. Particularly, the polymer nano particles with different sizes exhibit broadly tunable NIR absorption peaks from 630 to 811 nm. The PEGylated small polymer dots (Pdots) show good NIR light-harvesting efficiency and high non-radiative decay rates, resulting in a relatively high photothermal conversion efficiency in excess of 50%. Thus, this Pdot-based platform can serve as promising photothermal agents and photoacoustic probes for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordPhotothermal Therapy Photoacoustic Imaging Near-infrared Absorption Polymer Dots Contrast Agents
DOI10.1016/j.biomaterials.2017.08.007
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000411420000004
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:36   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, China
2.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China
3.Faculty of Health Science, University of Macau, Taipa 999078, Macau
Recommended Citation
GB/T 7714
Chen, Haobin,Zhang, Jian,Chang, Kaiwen,et al. Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy[J]. BIOMATERIALS,2017,144:42-52.
APA Chen, Haobin.,Zhang, Jian.,Chang, Kaiwen.,Men, Xiaoju.,Fang, Xiaofeng.,...&Wu, Changfeng.(2017).Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy.BIOMATERIALS,144,42-52.
MLA Chen, Haobin,et al."Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy".BIOMATERIALS 144(2017):42-52.
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