UM  > 中華醫藥研究院
Development of a Long-Lived Luminescence Probe for Visualizing beta-Galactosidase in Ovarian Carcinoma Cells
Wang, Wanhe1; Vellaisamy, Kasipandi1; Li, Guodong2; Wu, Chun1; Ko, Chung-Nga1; Leung, Chung-Hang2; Ma, Dik-Lung1
2017-11-07
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume89Issue:21Pages:11679-11684
Abstract

beta-Galactosidase (beta-gal) is an important biomarker for ovarian cancers. In this work, we designed and synthesized a novel iridium(III)-based probe 1 for discriminating ovarian carcinoma cell lines from normal cell lines. The probe could detect beta-gal even in the presence of a highly autofluorescent background. The probe also showed a good linear response to beta-gal between 0 and 30 U/mL, with a detection limit of 0.51 U/mL. Importantly, complex 1 could selectively "light up" ovarian carcinoma cells) while exhibiting negligible luminescence in normal cells. Overall, complex 1 could be potentially used as a useful probe for detecting beta-gal expression in the context of ovarian cancer diagnostics.

DOI10.1021/acs.analchem.7b03114
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000414887000073
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:56   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung, Chung-Hang; Ma, Dik-Lung
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Wanhe,Vellaisamy, Kasipandi,Li, Guodong,et al. Development of a Long-Lived Luminescence Probe for Visualizing beta-Galactosidase in Ovarian Carcinoma Cells[J]. ANALYTICAL CHEMISTRY,2017,89(21):11679-11684.
APA Wang, Wanhe.,Vellaisamy, Kasipandi.,Li, Guodong.,Wu, Chun.,Ko, Chung-Nga.,...&Ma, Dik-Lung.(2017).Development of a Long-Lived Luminescence Probe for Visualizing beta-Galactosidase in Ovarian Carcinoma Cells.ANALYTICAL CHEMISTRY,89(21),11679-11684.
MLA Wang, Wanhe,et al."Development of a Long-Lived Luminescence Probe for Visualizing beta-Galactosidase in Ovarian Carcinoma Cells".ANALYTICAL CHEMISTRY 89.21(2017):11679-11684.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Wanhe]'s Articles
[Vellaisamy, Kasipandi]'s Articles
[Li, Guodong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Wanhe]'s Articles
[Vellaisamy, Kasipandi]'s Articles
[Li, Guodong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Wanhe]'s Articles
[Vellaisamy, Kasipandi]'s Articles
[Li, Guodong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.