UM  > 健康科學學院
Venom-based peptide therapy: insights into anti-cancer mechanism
Ma, Rui; Mahadevappa, Ravikiran; Kwok, Hang Fai
2017-11-21
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:59Pages:100908-100930
Abstract

The 5-year relative survival rate of all types of cancer has increased significantly over the past three decades partly due to the targeted therapy. However, still there are many targeted therapy drugs could play a role only in a portion of cancer patients with specific molecular alternation. It is necessary to continue to develop new biological agents which could be used alone and/or in combination with current FDA approved drugs to treat complex cancer diseases. Venom-based drugs have been used for hundreds of years in human history. Nevertheless, the venom-origin of the anti-cancer drug do rarely appear in the pharmaceutical market; and this is due to the fact that the mechanism of action for a large number of the venom drug such as venom-based peptide is not clearly understood. In this review, we focus on discussing some identified venom-based peptides and their anti-cancer mechanisms including the blockade of cancer cell proliferation, invasion, angiogenesis, and metastasis (hallmarks of cancer) to fulfill the gap which is hindering their use in cancer therapy. Furthermore, it also highlights the importance of immunotherapy based on venom peptide. Overall, this review provides readers for further understanding the mechanism of venom peptide and elaborates on the need to explore peptide-based therapeutic strategies.

KeywordAnticancer Mechanism Venom Metastasis Targeted Therapy Signaling Pathway
DOIhttp://doi.org/10.18632/oncotarget.21740
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000419561600145
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai
AffiliationFaculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Ma, Rui,Mahadevappa, Ravikiran,Kwok, Hang Fai. Venom-based peptide therapy: insights into anti-cancer mechanism[J]. ONCOTARGET,2017,8(59):100908-100930.
APA Ma, Rui,Mahadevappa, Ravikiran,&Kwok, Hang Fai.(2017).Venom-based peptide therapy: insights into anti-cancer mechanism.ONCOTARGET,8(59),100908-100930.
MLA Ma, Rui,et al."Venom-based peptide therapy: insights into anti-cancer mechanism".ONCOTARGET 8.59(2017):100908-100930.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ma, Rui]'s Articles
[Mahadevappa, Ravikiran]'s Articles
[Kwok, Hang Fai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ma, Rui]'s Articles
[Mahadevappa, Ravikiran]'s Articles
[Kwok, Hang Fai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ma, Rui]'s Articles
[Mahadevappa, Ravikiran]'s Articles
[Kwok, Hang Fai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.