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A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis
Rajendran, Barani Kumar; Deng, Chu-Xia
2017-11-24
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:60Pages:102263-102276
Abstract

The giant multifunctional protein "OBSCURIN" is encoded by OBSCN gene and is mostly expressed in cardiac and other skeletal muscles responsible for myofibrils organization. Loss of OBSCURIN affects the entire downstream pathway proteins vital for various cellular functions including cell integration and cell adhesion. The OBSCN gene mutations are more frequently observed in various muscular diseases, and cancers. Nevertheless, the direct role of OBSCN in tumorigenesis remains elusive. Interestingly, in clinical breast cancer samples a significant number of function changing mutations have been identified in OBSCN gene. In this study, we identified a significant role of OBSCN by conducting an integrative analysis of copy number alterations, functional mutations, gene methylation and expression data from various BRCA cancer projects data available on cBioPortal and TCGA firebrowse portal. Finally, we carried out genetic network analysis, which revealed that OBSCN gene plays a significant role in GPCR, RAS, p75 or Wnt signaling pathways. Similarly, OBSCN gene interacts with many cancer-associated genes involved in breast tumorigenesis. The OBSCN gene probably regulates breast cancer progression and metastasis and the prognostic molecular signatures such as copy number alterations and gene expression of OBSCN may serve as a tool to identify breast tumorigenesis and metastasis.

KeywordBreast Cancer Obscn Gene Obscurin Cell Adhesion Emt
DOIhttp://doi.org/10.18632/oncotarget.20404
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000419533200105
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDeng, Chu-Xia
AffiliationCancer Research Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Rajendran, Barani Kumar,Deng, Chu-Xia. A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis[J]. ONCOTARGET,2017,8(60):102263-102276.
APA Rajendran, Barani Kumar,&Deng, Chu-Xia.(2017).A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis.ONCOTARGET,8(60),102263-102276.
MLA Rajendran, Barani Kumar,et al."A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis".ONCOTARGET 8.60(2017):102263-102276.
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