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Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer
Wang, Shengpeng1; Shao, Min2; Zhong, Zhangfeng1; Wang, Anqi1; Cao, Jiliang1; Lu, Yucong2; Wang, Yitao1; Zhang, Jinming1,3
2017-11-24
Source PublicationDRUG DELIVERY
ISSN1071-7544
Volume24Issue:1Pages:1791-1800
Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based combination therapy and gene therapy are new strategies to potentially overcome the limitations of TRAIL, however, the lack of efficient and low toxic vectors remains the major obstacle. In this study, we developed a hyaluronic acid (HA)-decorated polyethylenimine-poly(D, L-lactide-co-glycolide) (PEI-PLGA) nanoparticle (NP) system for targeted co-delivery of TRAIL plasmid (pTRAIL) and gambogic acid (GA) in triple-negative breast cancer (TNBC) therapy. GA was encapsulated into the core of the PEI-PLGA NPs while pTRAIL was adsorbed onto the positive NP surface via charge adsorption. The coating of HA on PEI-PLGA NPs functions as a targeting ligand by binding to CD44 receptor of TNBC cells and a shell to neutralize the excess positive charge of inner NPs. The resultant pTRAIL and GA co-loaded HA-coated PEI-PLGA NPs exhibited spherical shape (121.5nm) and could promote the internalization of loaded cargoes into TNBC cells through the CD44-dependent endocytic pathway. The dual drug-loaded NPs significantly augmented apoptotic cell death in vitro and inhibited TNBC tumor growth in vivo. This multifunctional NP system efficiently co-delivered GA and pTRAIL, thus representing a promising strategy to treat TNBC and bringing forth a platform strategy for co-delivery of therapeutic DNA and chemotherapeutic agents in combinatorial TNBC therapy.

KeywordNanoparticles Trail Gambogic Acid Triple Negative Breast Cancer Co-delivery
DOIhttp://doi.org/10.1080/10717544.2017.1406558
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000424462500002
PublisherTAYLOR & FRANCIS LTD
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Yitao; Zhang, Jinming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Bioengineering, Zunyi Medical University Zhuhai Campus, Zhuhai, Guangdong, China
3.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Shengpeng,Shao, Min,Zhong, Zhangfeng,et al. Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer[J]. DRUG DELIVERY,2017,24(1):1791-1800.
APA Wang, Shengpeng.,Shao, Min.,Zhong, Zhangfeng.,Wang, Anqi.,Cao, Jiliang.,...&Zhang, Jinming.(2017).Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer.DRUG DELIVERY,24(1),1791-1800.
MLA Wang, Shengpeng,et al."Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer".DRUG DELIVERY 24.1(2017):1791-1800.
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