UM
Transgenerational toxicity of nanopolystyrene particles in the range of mu g L-1 in the nematode Caenorhabditis elegans
Zhao, Li; Qu, Man; Wong, Garry; Wang, Dayong
2017-12
Source PublicationENVIRONMENTAL SCIENCE-NANO
ISSN2051-8153
Volume4Issue:12Pages:2356-2366
AbstractThe potential toxicity of nanoplastics to environmental organisms has gradually received great attention recently. We employed the in vivo assay system of Caenorhabditis elegans to investigate the possible transgenerational toxicity of nanopolystyrene particles and the underlying cellular mechanisms. After prolonged exposure, we observed the toxicity of nanopolystyrene particles at concentrations higher than 10 mu g L-1. The transgenerational toxicity was further detected in nematodes exposed to nanopolystyrene particles at concentrations higher than 100 mu g L-1. This observed transgenerational toxicity of nanopolystyrene particles might be mainly due to the translocation of nanopolystyrene particles into reproductive organs such as the gonad, which potentially in turn led to the transfer of nanopolystyrene particles to the next generation. Leachates from nanopolystyrene particles at concentrations in the range of mu g L-1 did not contribute to the development of this transgenerational toxicity. Enhancement of intestinal permeability and extension of defecation cycle length provide the explanation for the observed accumulation and translocation of nanopolystyrene particles in reproductive organs. Therefore, our results demonstrate the potential transgenerational toxicity of nanopolystyrene particles in the range of mu g L-1 in environmental organisms.
DOI10.1039/c7en00707h
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Environmental Sciences & Ecology ; Science & Technology - Other Topics
WOS SubjectChemistry, Multidisciplinary ; Environmental Sciences ; Nanoscience & Nanotechnology
WOS IDWOS:000417463300010
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zhao, Li,Qu, Man,Wong, Garry,et al. Transgenerational toxicity of nanopolystyrene particles in the range of mu g L-1 in the nematode Caenorhabditis elegans[J]. ENVIRONMENTAL SCIENCE-NANO,2017,4(12):2356-2366.
APA Zhao, Li,Qu, Man,Wong, Garry,&Wang, Dayong.(2017).Transgenerational toxicity of nanopolystyrene particles in the range of mu g L-1 in the nematode Caenorhabditis elegans.ENVIRONMENTAL SCIENCE-NANO,4(12),2356-2366.
MLA Zhao, Li,et al."Transgenerational toxicity of nanopolystyrene particles in the range of mu g L-1 in the nematode Caenorhabditis elegans".ENVIRONMENTAL SCIENCE-NANO 4.12(2017):2356-2366.
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