UM
Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury
Cheng, Ni; Liang, Yurong; Du, Xiaoping; Ye, Richard D.
2018-10
Source PublicationEMBO REPORTS
ISSN1469-221X
Volume19Issue:10
AbstractLipopolysaccharide (LPS) is a major microbial mediator for tissue injury and sepsis resulting from Gram-negative bacterial infection. LPS is an external factor that induces robust expression of serum amyloid A (SAA), a major constituent of the acute-phase proteins, but the relationship between SAA expression and LPS-induced tissue injury remains unclear. Here, we report that mice with inducible transgenic expression of human SAA1 are partially protected against inflammatory response and lung injury caused by LPS and cecal ligation and puncture (CLP). In comparison, transgenic SAA1 does not attenuate TNF-induced lung inflammation and injury. The SAA1 expression level correlates inversely with the endotoxin concentrations in serum and lung tissues since SAA1 binds directly to LPS to form a complex that promotes LPS uptake by macrophages. Disruption of the SAA1-LPS interaction with a SAA1-derived peptide partially reduces the protective effect and exacerbates inflammation. These findings demonstrate that acute-phase SAA provides innate feedback protection against LPS-induced inflammation and tissue injury.
Keywordacute-phase response inflammation innate immunity lipopolysaccharide serum amyloid A
DOI10.15252/embr.201745517
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000446430400006
PublisherWILEY
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Cheng, Ni,Liang, Yurong,Du, Xiaoping,et al. Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury[J]. EMBO REPORTS,2018,19(10).
APA Cheng, Ni,Liang, Yurong,Du, Xiaoping,&Ye, Richard D..(2018).Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury.EMBO REPORTS,19(10).
MLA Cheng, Ni,et al."Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury".EMBO REPORTS 19.10(2018).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cheng, Ni]'s Articles
[Liang, Yurong]'s Articles
[Du, Xiaoping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cheng, Ni]'s Articles
[Liang, Yurong]'s Articles
[Du, Xiaoping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cheng, Ni]'s Articles
[Liang, Yurong]'s Articles
[Du, Xiaoping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Cheng-2018-Serum-amyloid-a-promotes-lps-cleara.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.