UM
Akt downstream of NF kappa B, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP
Li, Zhi-Peng; Li, Li-Feng; Zhang, Quan-Wei; Wei, Wei; Liu, Hong-Bing; Sao, Wan-Rong; Ma, Dik-Lung; Leung, Chung-Hang; Bian, Zhao-Xiang; Lu, Ai-Ping; Han, Quan-Bin
2017-12
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume39Pages:152-159
AbstractPolysaccharides are considered the main active ingredient for the immune-enhancing effect of Radix Astragali, which is popularly used as medicinal food supplementary. The signal pathways involved in immune-enhancing effect remain unclear. This study is to investigate the role and regulation relation of Akt pathway with downstream kinases of TLR4 receptor in macrophages induced by Astragalus polysaccharide, RAP. The results showed that RAP induced phosphorylation of Akt, NF kappa B, IRF3 and MAPKs in RAW264.7 cells, and their individual inhibitors not only inhibited their inflammatory factors production and gene expression, but also suppressed the Akt phosphorylation, while Akt inhibitor exerted no effect on MAPKs, NF kappa B, and IRF3 phosphorylation. Taken together, these results suggested that Akt and IRF3 exerted activation role in RAP induced macrophage, and Akt exerted effect downstream of MyD88 dependent and independent pathway. This study will provide a deeper insight into the signal transduction induced by Astragalus polysaccharides. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordPolysaccharide Inflammatory MyD88 Phosphorylation RAW264.7
DOI10.1016/j.jff.2017.10.004
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000418206000019
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Li, Zhi-Peng,Li, Li-Feng,Zhang, Quan-Wei,et al. Akt downstream of NF kappa B, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP[J]. JOURNAL OF FUNCTIONAL FOODS,2017,39:152-159.
APA Li, Zhi-Peng.,Li, Li-Feng.,Zhang, Quan-Wei.,Wei, Wei.,Liu, Hong-Bing.,...&Han, Quan-Bin.(2017).Akt downstream of NF kappa B, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP.JOURNAL OF FUNCTIONAL FOODS,39,152-159.
MLA Li, Zhi-Peng,et al."Akt downstream of NF kappa B, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP".JOURNAL OF FUNCTIONAL FOODS 39(2017):152-159.
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