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Anticancer carbazole alkaloids and coumarins from Clausena plants: A review
Huang Li; Feng Zhe-Ling; Wang Yi-Tao; Lin Li-Gen
2017-12
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume15Issue:12Pages:881-888
Abstract

Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.

KeywordClausena Anticancer Carbazole Alkaloids Coumarins
DOIhttps://doi.org/10.1016/S1875-5364(18)30003-7
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000419593800001
PublisherCHINESE JOURNAL NATURAL MEDICINES
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin Li-Gen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang Li,Feng Zhe-Ling,Wang Yi-Tao,et al. Anticancer carbazole alkaloids and coumarins from Clausena plants: A review[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2017,15(12):881-888.
APA Huang Li,Feng Zhe-Ling,Wang Yi-Tao,&Lin Li-Gen.(2017).Anticancer carbazole alkaloids and coumarins from Clausena plants: A review.CHINESE JOURNAL OF NATURAL MEDICINES,15(12),881-888.
MLA Huang Li,et al."Anticancer carbazole alkaloids and coumarins from Clausena plants: A review".CHINESE JOURNAL OF NATURAL MEDICINES 15.12(2017):881-888.
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