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Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal
Wang, Ya-Fang; Tang, Zheng-Hai; Li, Ting; Xu, Xiao-Huang; Chen, Xiuping; Wang, Ying; Wang, Yi-Tao; Lu, Jin-Jian
2017-12
Source PublicationMOLECULAR MEDICINE REPORTS
ISSN1791-2997
Volume16Issue:6Pages:8392-8398
Abstract

Baicalein (BA), one of the major bioactive flavonoids isolated from Scutellariae Radix, possesses various pharmacological activities. The present study aimed to investigate the protective effects of BA on tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity, and to investigate the potential mechanisms in LO2 cells. BA was demonstrated to possess protective properties against t-BHP injury in LO2 cells, as evidenced by MTT and lactate dehydrogenase assays. BA significantly prevented t-BHP-induced depolarization of mitochondrial membrane potential (MMP), decreased the percentage of apoptotic cells caused by t-BHP, and prevented intracellular reactive oxygen species (ROS) generation in LO2 cells. Furthermore, BA slightly triggered autophagy in LO2 cells, as evidenced by the elevation of LC3-II expression, while BA combined treatment with an autophagy inhibitor (chloroquine) or activator (rapamycin) did not alter the hepatoprotective properties. In conclusion, BA may possess a hepatoprotective effect against t-BHP-induced liver cell injury, dependent on ROS removal. Therefore, BA may represent a potential drug candidate in protecting hepatotoxicity.

KeywordBaicalein Liver Protection Reactive Oxygen Species Apoptosis
DOIhttp://doi.org/10.3892/mmr.2017.7592
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000418229200065
PublisherSPANDIDOS PUBL LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Yi-Tao
AffiliationState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau 999078, P.R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Ya-Fang,Tang, Zheng-Hai,Li, Ting,et al. Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal[J]. MOLECULAR MEDICINE REPORTS,2017,16(6):8392-8398.
APA Wang, Ya-Fang.,Tang, Zheng-Hai.,Li, Ting.,Xu, Xiao-Huang.,Chen, Xiuping.,...&Lu, Jin-Jian.(2017).Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal.MOLECULAR MEDICINE REPORTS,16(6),8392-8398.
MLA Wang, Ya-Fang,et al."Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal".MOLECULAR MEDICINE REPORTS 16.6(2017):8392-8398.
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