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Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats
Chen, Xiao-Xin1; Lam, Kar Ho1; Chen, Qing-Xi2; Leung, George Pak-Heng3; Tang, Sydney Chi Wai4; Sze, Stephen Cho-Wing1; Xiao, Jian-Bo5; Feng, Feng6; Wang, Ying7; Zhang, Kalin Yan-Bo1; Zhang, Zhang-Jin1
2017-12
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
Volume110Pages:49-61
Abstract

5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for breast cancer. However, its use often leads to drug resistance and mucositis. This study aimed to investigate whether proanthocyanidins from Ficus virens possessed anti-breast cancer and anti-mucositis activities. The results showed that the cytotoxic effects of the proanthocyanidins against MDA-MB-231 and MCF-7 breast cancer cells were in the order of stem barks proanthocyanidins (SPAs) > leaves proanthocyanidins > fruits proanthocyanidins. Moreover, SPAs induced apoptosis in both cell lines which were accompanied with an increase in loss of mitochondrial membrane potential, production of reactive oxygen species, Box to Bcl-2 protein expression ratio, and activated caspase 3. Furthermore, intraperitoneal injection of 5-FU (150 mg/kg body weight) resulted in body weight loss and jejunal injury in the rats while administration of SPAs (100 mg/kg body weight) counteracted these changes. Collectively, our study demonstrated that SPAs induced apoptosis cell death in breast cancer cells while ameliorating the symptoms of intestinal mucositis in rats.Therefore, SPAs merits further exploration as a potential therapeutic agent for breast cancer and chemotherapy-induced mucositis.

KeywordFicus Virens Proanthocyanidins Breast Cancer Apoptosis 5-fluorouracil Mucositis
DOI10.1016/j.fct.2017.10.017
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000418211700006
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong
2.Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
3.Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
4.Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, 102 Pokfulam Road, Hong Kong
5.Institute of Chinese Medical Sciences, University of Macau (UM).N22 Research Building, Avenida da Universidade, Taipa, Macau, China
6.Department of Natural Products Chemistry, Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Jiangning, China
7.Department of Histopathology, Sichuan Cancer Hospital, 55 Tongzi Lin Road, Chengdu, Sichuan, China
Recommended Citation
GB/T 7714
Chen, Xiao-Xin,Lam, Kar Ho,Chen, Qing-Xi,et al. Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2017,110:49-61.
APA Chen, Xiao-Xin.,Lam, Kar Ho.,Chen, Qing-Xi.,Leung, George Pak-Heng.,Tang, Sydney Chi Wai.,...&Zhang, Zhang-Jin.(2017).Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats.FOOD AND CHEMICAL TOXICOLOGY,110,49-61.
MLA Chen, Xiao-Xin,et al."Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats".FOOD AND CHEMICAL TOXICOLOGY 110(2017):49-61.
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