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The Role of G Protein-coupled Receptor Kinases in Cancer
Yu, Shan1; Sun, Litao2; Jiao, Yufei3; Lee, Leo Tsz On1
2018
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume14Issue:2Pages:189-203
Abstract

G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. Emerging evidence demonstrates that signaling through GPCRs affects numerous aspects of cancer biology such as vascular remolding, invasion, and migration. Therefore, development of GPCR-targeted drugs could provide a new therapeutic strategy to treating a variety of cancers. G protein-coupled receptor kinases (GRKs) modulate GPCR signaling by interacting with the ligand-activated GPCR and phosphorylating its intracellular domain. This phosphorylation initiates receptor desensitization and internalization, which inhibits downstream signaling pathways related to cancer progression. GRKs can also regulate non-GPCR substrates, resulting in the modulation of a different set of pathophysiological pathways. In this review, we will discuss the role of GRKs in modulating cell signaling and cancer progression, as well as the therapeutic potential of targeting GRKs.

Keywordg Protein-coupled Receptor (Gpcr) g Protein-coupled Receptor Kinase (Grk) Cancer Cell Signaling
DOI10.7150/ijbs.22896
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000425857500001
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Centre of Reproduction Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau
2.Department of Ultrasound, The Secondary Affiliated Hospital of Harbin Medical University, Harbin, China
3.Department of Pathology, The Secondary Affiliated Hospital of Harbin Medical University, Harbin, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yu, Shan,Sun, Litao,Jiao, Yufei,et al. The Role of G Protein-coupled Receptor Kinases in Cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2018,14(2):189-203.
APA Yu, Shan,Sun, Litao,Jiao, Yufei,&Lee, Leo Tsz On.(2018).The Role of G Protein-coupled Receptor Kinases in Cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14(2),189-203.
MLA Yu, Shan,et al."The Role of G Protein-coupled Receptor Kinases in Cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14.2(2018):189-203.
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