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A μNMR CMOS Transceiver Using a Butterfly-Coil Input for Integration With a Digital Microfluidic Device Inside a Portable Magnet
Ka-Meng Lei1; Pui-In Mak1; Man-Kay Law2; Rui P. Martins3
2016-10-01
Source PublicationIEEE Journal of Solid-State Circuits
ISSN00189200
Volume51Issue:10Pages:2274-2286
Abstract

This paper describes a 20 MHz micro-nuclear magnetic resonance (μNMR) transceiver (TRX) featuring a butterflycoil input for chemical/biological assays. It enables integration with a 2D multi-electrode digital microfluidic (DMF) device inside a space-limited portable magnet (0.46 T, 1.25 kg), making multisample management compatible with μNMR measurements, and supporting electronic automation. The transmitter (TX) incorporates a pulse-sequence synthesizer followed by an inverter-based power amplifier (PA), to emit the exciting pulses for magnetizing the protons of the samples. For the receiver (RX), it is headed by a multi-stage low-noise amplifier (LNA) using NMOS-PMOScomplementary differential pairs, achieving a sub-nV/√Hz inputreferred noise at low power. Sixth-order Butterworth low-pass filters constitute the core of the RX I/Q baseband. Their sourcefollower- based topology allows fast and coherent scaling of all poles by the bias current, reducing the dead-time of the RX for better sensitivity. Fabricated in 0.18 μm CMOS, the TRX occupies a die area of 2.1 mm, consumes 6.6/23.7 mW of power in the TX/RX mode, and demonstrates the feasibility of electronic-automated biological (avidin) and chemical (CuSO) assays achieving a detection limit on avidin of 0.2 pmol.

KeywordAvidin Baseband Biological Chemical Cmos Digital Microfluidic (Dmf) Electronic Automation Filter Low-noise Amplifier (Lna) Magnetic Sensing Nuclear Magnetic Resonance (Nmr) Point-of-care Power Amplifier (Pa) Radio Frequency (Rf) Receiver (Rx) Transceiver (Trx) Transmitter (Tx)
DOIhttp://doi.org/10.1109/JSSC.2016.2579158
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Electrical & Electronic
WOS IDWOS:000385240200011
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被引频次[WOS]:3   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
INSTITUTE OF MICROELECTRONICS
Corresponding AuthorPui-In Mak
Affiliation1.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECE, University of Macau, Macao, China
2.State-Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macao, China
3.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECE, University of Macau, Macao, China, on leave from Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, Lisbon
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
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Ka-Meng Lei,Pui-In Mak,Man-Kay Law,et al. A μNMR CMOS Transceiver Using a Butterfly-Coil Input for Integration With a Digital Microfluidic Device Inside a Portable Magnet[J]. IEEE Journal of Solid-State Circuits,2016,51(10):2274-2286.
APA Ka-Meng Lei,Pui-In Mak,Man-Kay Law,&Rui P. Martins.(2016).A μNMR CMOS Transceiver Using a Butterfly-Coil Input for Integration With a Digital Microfluidic Device Inside a Portable Magnet.IEEE Journal of Solid-State Circuits,51(10),2274-2286.
MLA Ka-Meng Lei,et al."A μNMR CMOS Transceiver Using a Butterfly-Coil Input for Integration With a Digital Microfluidic Device Inside a Portable Magnet".IEEE Journal of Solid-State Circuits 51.10(2016):2274-2286.
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