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Cisplatin-prodrug-constructed liposomes as a versatile theranostic nano-platform for bimodal imaging guided combination cancer therapy
Liangzhu Feng1,2; Min Gao2; Danlei Tao2; Qian Chen2; Hairong Wang2; Ziliang Dong2; Meiwan Chen1; Zhuang Liu2
2016
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume26Issue:13Pages:2207-2217
Abstract

Up to date, a large variety of liposomal nanodrugs have been explored for cancer nanomedicine, showing encouraging results in both preclinical animal experiments and clinical treatment of cancer patients. Herein, a phospholipid conjugated with a cisplatin prodrug is used as the major structure component of liposomes together with other commercial lipids via self‐assembling. By doping with 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindotricarbocyanine iodide (DiR), a lipophilic dye with strong near infrared (NIR) absorbance and fluorescence, the obtained DiR‐Pt(IV)‐liposome is found to be an effective probe for in vivo NIR fluorescence and photoacoustic bimodal imaging. Attributing to its intrinsically doped cis‐Pt(IV) prodrug, efficient photothermal conversion ability, and excellent tumor homing ability, DiR‐Pt(IV)‐liposome confers greatly enhanced therapeutic outcomes in the combined photothermal‐chemotherapy. Moreover, Pt(IV)‐liposome is also demonstrated to be an efficient carrier for both small hydrophilic molecules and proteins, which are encapsulated inside the water‐cavity of liposomes, further demonstrating the versatile functions of this nanoplatform. This study develops a unique type of liposomal nanomedicine with a prodrug conjugated phospholipid as the major structure component. Such Pt(IV)‐liposome is featured with advantages including precisely defined/easily tunable drug compositions, stealth‐like pharmacokinetics, efficient tumor passive uptake, and the capabilities to simultaneously load with various types of imaging or therapeutic agents.

DOIhttps://doi.org/10.1002/adfm.201504899
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000373738000016
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Cited Times [WOS]:74   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau 999078 , China
2.Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liangzhu Feng,Min Gao,Danlei Tao,et al. Cisplatin-prodrug-constructed liposomes as a versatile theranostic nano-platform for bimodal imaging guided combination cancer therapy[J]. Advanced Functional Materials,2016,26(13):2207-2217.
APA Liangzhu Feng.,Min Gao.,Danlei Tao.,Qian Chen.,Hairong Wang.,...&Zhuang Liu.(2016).Cisplatin-prodrug-constructed liposomes as a versatile theranostic nano-platform for bimodal imaging guided combination cancer therapy.Advanced Functional Materials,26(13),2207-2217.
MLA Liangzhu Feng,et al."Cisplatin-prodrug-constructed liposomes as a versatile theranostic nano-platform for bimodal imaging guided combination cancer therapy".Advanced Functional Materials 26.13(2016):2207-2217.
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