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Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs
Yancai Wang; Xiaoqing Miao; Lin Sun; Ju Song; Chao Bi; Xiao Yang; Ying Zheng
2014
Source PublicationCurrent Pharmaceutical Design
ISSN1381-6128
Volume20Issue:3Pages:454 - 473
Abstract

A surprisingly large proportion of new chemical entities (NCE) is emerging from the drug discovery pipeline, and many active components extracted from herbal medicines are water insoluble, which represents a great challenge for their development. Nanosuspensions, which are submicron colloidal dispersions of pure drug particles that are stabilised by a small percentage of the excipients, could dramatically enhance the saturated solubility, dissolution rate and adhesion of drug particles to cell membranes. Nanosuspensions are the most suitable for drugs that require high dosing or have limited administrative volume. After 20 years of development, several oral products and one injectable product are commercially available. The aim of this review is to fill the gap between rational formulation designs and the in vivo performance of poorly water-soluble drug nanosuspensions. Specifically, this review will correlate characteristics of nanosuspension formulations, including drug property, particle size, crystallinity, stabiliser and surface property, with their transport, pharmacokinetics, bioactivity and toxicity after delivery by different administration routes. The elucidation of the mechanisms of targeted drug delivery, cellular transport and internalisation of nanosuspensions are also reviewed to interpret the in vivo performance of these nanosuspensions. Moreover, the recent application of nanosuspensions for poorly water-soluble herbal medicines is highlighted.

KeywordNanosuspensions Absorption Pharmacokinetics Drug Targeting Transport Efficacy Toxicity
DOIhttps://doi.org/10.2174/13816128113199990403
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000334303800009
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被引频次[WOS]:9   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Institute of Chinese Medical Sciences
AffiliationInstitute of Chinese Medical Sciences, University of Macau, 3/F, Rm 204A, Block 3, Av. Padre Tomás Pereira, S.J. Taipa, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
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Yancai Wang,Xiaoqing Miao,Lin Sun,et al. Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs[J]. Current Pharmaceutical Design,2014,20(3):454 - 473.
APA Yancai Wang.,Xiaoqing Miao.,Lin Sun.,Ju Song.,Chao Bi.,...&Ying Zheng.(2014).Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs.Current Pharmaceutical Design,20(3),454 - 473.
MLA Yancai Wang,et al."Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs".Current Pharmaceutical Design 20.3(2014):454 - 473.
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