UM  > Faculty of Health Sciences
Complex Alternative Splicing
Jung Woo Park; Brenton R. Graveley
2007
Source PublicationAlternative splicing in the postgenomic era
PublisherSpringer-Verlag New York
Pages50-63
Abstract

Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands, and even tens of thousands of isoforms. Collectively such genes are considered to undergo complex alternative splicing. The best example is the Drosophila Down syndrome cell adhesion molecule (Dscam) gene, which can generate 38,016 isoforms by the alternative splicing of 95 variable exons. In this review, we will describe several genes that use complex alternative splicing to generate large repertoires of mRNAs and what is known about the mechanisms by which they do so.

DOIhttps://doi.org/10.1261/rna.1340908
Language英语
ISBN978-0-387-77373-5
Fulltext Access
Citation statistics
Document TypeBook chapter
CollectionFaculty of Health Sciences
AffiliationDepartment of Genetics and Developmental Biology University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030-3301
Recommended Citation
GB/T 7714
Jung Woo Park,Brenton R. Graveley. Complex Alternative Splicing:Springer-Verlag New York,2007:50-63.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jung Woo Park]'s Articles
[Brenton R. Graveley]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jung Woo Park]'s Articles
[Brenton R. Graveley]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jung Woo Park]'s Articles
[Brenton R. Graveley]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.