UM  > 健康科學學院
The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System
J.Y.S. Chu; L.T.O. Lee; F.K.Y. Siu; B.K.C. Chow
2006
Source PublicationCentral Nervous System Agents in Medicinal Chemistry
ISSN1871-5249
Volume6Issue:1Pages:27-57
Abstract

The secretin/PACAP/VIP superfamily contains at least ten brain-gut peptides, including secretin, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), glucagon, glucagon-like peptide- (GLP-1), glucagon like peptide-2 (GLP-2), gastric inhibitory polypeptide (GIP), peptide histidine isoleucine (PHI) or peptide histidine methionine (PHM), and growth hormone-releasing hormone (GHRH). These peptides exhibit a wide tissue distribution in the peripheral systems, indicating their pleiotrophic actions in the body. Meanwhile, their functions in the central nervious system (CNS) have also been consolidated recently. For instance, most of these peptides have shown to serve as neurotransmitters, neuromodulators, neurotrophic factors, and/or neurohormones in the brain, and hence, their potential as novel CNS agents in treating neurological disorders including Autism, Alzheimer’s disease, Parkinson’s disease and HIV-associated neuronal cell death were recently exploited. In this article, recent progress in research of peptides in this family with particular emphasis on structures, their central functions and potential use in the treatment of neuronal diseases are reviewed.

KeywordSecretin/vip/pacap Family Peptides Neuropathological Diseases Chemical Structure Central Nervous System Physiological Actions
DOIhttp://dx.doi.org/10.2174/187152406776056546
Indexed By其他
Language英语
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorB.K.C. Chow
AffiliationDepartment of Zoology, The University of Hong Kong, Hong Kong, SAR, People's Republic of China
Recommended Citation
GB/T 7714
J.Y.S. Chu,L.T.O. Lee,F.K.Y. Siu,et al. The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System[J]. Central Nervous System Agents in Medicinal Chemistry,2006,6(1):27-57.
APA J.Y.S. Chu,L.T.O. Lee,F.K.Y. Siu,&B.K.C. Chow.(2006).The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System.Central Nervous System Agents in Medicinal Chemistry,6(1),27-57.
MLA J.Y.S. Chu,et al."The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System".Central Nervous System Agents in Medicinal Chemistry 6.1(2006):27-57.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[J.Y.S. Chu]'s Articles
[L.T.O. Lee]'s Articles
[F.K.Y. Siu]'s Articles
Baidu academic
Similar articles in Baidu academic
[J.Y.S. Chu]'s Articles
[L.T.O. Lee]'s Articles
[F.K.Y. Siu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[J.Y.S. Chu]'s Articles
[L.T.O. Lee]'s Articles
[F.K.Y. Siu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.