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Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies
RanKe; XinMa; Leo T.O.Lee
2018
Source PublicationPeptides
ISSN0196-9781
Abstract

It is widely acknowledged that kisspeptin and its receptor Kiss1R play central regulatory roles in the hypothalamus-
pituitary-gonad (HPG) axis and reproduction. Mutations of KISS1 and KISS1R lead to disorders associated
with pubertal development, such as central precocious puberty (CPP) and idiopathic hypogonadotropic hypogonadism
(IHH). This review focuses on KISS1 and KISS1R mutations found in CPP and IHH and its purposes are
twofold: Firstly, based on the mutations found in KISS1 and KISS1R, this review provides insights into the precise
mechanism of kisspeptin and the kisspeptin/Kiss1R pathway in the reproductive axis and in puberty. Secondly, G
protein-coupled receptors (GPCRs) are known to share highly conserved structural motifs; therefore, knowledge
of mutations found at different structural domains of Kiss1R in the diseased state, and how they affect Kiss1R
function can be used to decipher GPCR domain function.

KeywordKisspeptin Central Precocious Puberty Idiopathic Hypogonadotropic Hypogonadism Receptor Signaling Reproductive System
DOIhttps://doi.org/10.1016/j.peptides.2018.09.007
Indexed By其他
Language英语
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Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationCentre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
RanKe,XinMa,Leo T.O.Lee. Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies[J]. Peptides,2018.
APA RanKe,XinMa,&Leo T.O.Lee.(2018).Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies.Peptides.
MLA RanKe,et al."Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies".Peptides (2018).
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