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Evolution of parathyroid hormone receptor family and their ligands in vertebrate
On, Jason S. W.; Chow, Billy K. C.; Lee, Leo T. O.
2015
Source PublicationFRONTIERS IN ENDOCRINOLOGY
ISSN1664-2392
Volume6
Abstract

The presence of the parathyroid hormones in vertebrates, including PTH, PTH-related peptide (PTHrP), and tuberoinfundibular peptide of 39 residues (TIP39), has been proposed to be the result of two rounds of whole genome duplication in the beginning of vertebrate diversification. Bioinformatics analyses, in particular chromosomal synteny study and the characterization of the PTH ligands and their receptors from various vertebrate species, provide evidence that strongly supports this hypothesis. In this mini-review, we summarize recent advances in studies regarding the molecular evolution and physiology of the PTH ligands and their receptors, with particular focus on non-mammalian vertebrates. In summary, the PTH family of peptides probably predates early vertebrate evolution, indicating a more ancient existence as well as a function of these peptides in invertebrates.

KeywordParathyroid Hormone Parathyroid Hormone Receptor Evolution Vertebrate g Protein-coupled Receptor
DOIhttps://doi.org/10.3389/fendo.2015.00028
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000378404500001
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLee, Leo T. O.
AffiliationUniv Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
On, Jason S. W.,Chow, Billy K. C.,Lee, Leo T. O.. Evolution of parathyroid hormone receptor family and their ligands in vertebrate[J]. FRONTIERS IN ENDOCRINOLOGY,2015,6.
APA On, Jason S. W.,Chow, Billy K. C.,&Lee, Leo T. O..(2015).Evolution of parathyroid hormone receptor family and their ligands in vertebrate.FRONTIERS IN ENDOCRINOLOGY,6.
MLA On, Jason S. W.,et al."Evolution of parathyroid hormone receptor family and their ligands in vertebrate".FRONTIERS IN ENDOCRINOLOGY 6(2015).
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